Albayrak Ayse, Seda Gunbey Sibel, Aktas Ferda
Departments of Infectious Diseases and Clinical Microbiology, Erzurum Region Education and Research Hospital;
Department of Clinical Microbiology, Erzurum Region Education and Research Hospital, Turkey.
Clin Pract. 2011 Apr 11;1(1):e13. doi: 10.4081/cp.2011.e13. eCollection 2011 Mar 29.
Salmonella infection occurs worldwide and is still an important public health problem in many developing countries. The infection can affect almost all major organs including the liver. Severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. In this paper, a 39-year-old male with acute cholestatic typhoid hepatitis is presented. The case had a tender hepatomegaly and elevated serum alanine and aspartate transaminase, alkaline phosphatase, and gamma glutamyl transferase levels; these features cannot been distinguished from those of acute viral hepatitis. Serological and viral markers of acute viral hepatitis were negative. No pathology could be determined in abdomen Ultrasonography (USG) or Magnetic Resonance (MR) Cholangiography. As enteric fever is a common infection, the recognition of salmonella hepatitis is of clinical importance. When patients from an endemic or outbreak area present acute febrile hepatitis, typhoid fever should be a consideration.
沙门氏菌感染在全球范围内都有发生，在许多发展中国家仍然是一个重要的公共卫生问题。这种感染几乎会影响包括肝脏在内的所有主要器官。严重的肝脏受累并伴有急性肝炎的临床特征是一种罕见的并发症。本文报告了一名39岁患有急性胆汁淤积性伤寒肝炎的男性病例。该病例有肝脏触痛肿大，血清丙氨酸和天冬氨酸转氨酶、碱性磷酸酶以及γ-谷氨酰转移酶水平升高；这些特征与急性病毒性肝炎无法区分。急性病毒性肝炎的血清学和病毒标志物均为阴性。腹部超声（USG）或磁共振（MR）胆管造影均未发现病理改变。由于伤寒热是一种常见感染，认识到沙门氏菌肝炎具有临床重要性。当来自流行地区或暴发地区的患者出现急性发热性肝炎时，应考虑伤寒热。
