Senadhi Viplove
Johns Hopkins University/Sinai Hospital Program in Internal Medicine, Baltimore, MD, USA.
Clin Pract. 2011 Apr 15;1(1):e18. doi: 10.4081/cp.2011.e18. eCollection 2011 Mar 29.
Hepatitis C most commonly manifests with asymptomatic elevations in transaminase levels or in advanced stages, may present with hepatic encephalopathy or ascites. We report the first case in the literature, in which the initial manifestation of hepatitis C induced chronic liver disease was recurrent hypoglycemia and hypothermia. In our case, the hypoglycemia was induced by glycogen depletion from hepatitis C induced chronic liver disease. In chronic liver disease, glycogen stores are depleted from extensive fibrosis and it has been shown that glycogen depletion may herald hepatic encephalopathy, which later manifested in our patient.
丙型肝炎最常见的表现是转氨酶水平无症状升高，或在晚期可能出现肝性脑病或腹水。我们报告了文献中的首例病例，其中丙型肝炎诱发的慢性肝病的初始表现为反复低血糖和体温过低。在我们的病例中，低血糖是由丙型肝炎诱发的慢性肝病导致糖原耗竭引起的。在慢性肝病中，广泛的纤维化会使糖原储备耗尽，并且已经表明糖原耗竭可能预示着肝性脑病，而这在我们的患者中后来出现了。
