Cedeño Diaz Oderay Mabel, Leal Roberto García, La Cruz Pelea Cesar
Departments of Surgical Pathology and.
Neurosurgery, Gregorio Marañn General Hospital, Madrid, Spain.
Clin Pract. 2011 Jun 21;1(2):e31. doi: 10.4081/cp.2011.e31. eCollection 2011 May 16.
Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.
原发性松果体恶性黑色素瘤是一种罕见的疾病，迄今为止世界文献中仅报道了13例。我们报告一例70岁男性，因步态不稳6个月前来就诊，近1个月伴有头晕、视觉异常和复视。在其他部位未发现其他额外的黑素细胞病变。磁共振成像显示松果体区有一个25mm的占位性肿块，伴有脑积水、脑室及经室管膜水肿。通过小脑上幕下入路对病变进行了部分切除。组织学检查显示为黑色素瘤。患者接受了放射治疗，但16周后死于该疾病。我们在此回顾了关于这种罕见肿瘤的文献，并对其临床、放射学和组织病理学特征及鉴别诊断进行了评论。
