Frigui Makram, Kechaou Manel, Jallouli Moez, Kaddour Neila, Chaabouni Habiba Bouhamed, Bahloul Zouhir
Department of Internal medicine, Hedi Chaker Hospital, Sfax;
Laboratory of Human genetics, Tunis medicine college, Tunis, Tunisia.
Clin Pract. 2011 May 6;1(2):e34. doi: 10.4081/cp.2011.e34. eCollection 2011 May 16.
Behçet's disease (BD) and familial Mediterranean fever (FMF), which are two separate diseases sharing some clinical features, may also coexist in the same patient. Further investigations are needed to understand whether this coexistence is due to either chance or geographical distribution patterns of these diseases or to common etiopathogenetic characteristics. Spondylarthritis as part of the clinical picture in these two diseases has been questioned and probably it is not a prominent characteristic of any of them. We report a 35-year-old Tunisian man who had an association of BD, FMF and Human Leukocyte Antigen (HLA) B27 positive ankylosing spondylitis. Although that spondylarthritis is an infrequent joint involvement of FMF and BD, it must be looked for in case of association of these diseases.
白塞病（BD）和家族性地中海热（FMF）是两种具有一些共同临床特征的不同疾病，它们也可能在同一患者中共存。需要进一步研究以了解这种共存是由于偶然因素、这些疾病的地理分布模式还是共同的病因发病特征。这两种疾病临床表现中的脊柱关节炎部分一直存在疑问，可能它并非其中任何一种疾病的突出特征。我们报告了一名35岁的突尼斯男子，他同时患有白塞病、家族性地中海热和人类白细胞抗原（HLA）B27阳性的强直性脊柱炎。虽然脊柱关节炎在家族性地中海热和白塞病中是较少见的关节受累情况，但在这两种疾病并存的情况下必须予以排查。
