Yonehara N, Tsai H Y, Chen J Q, Inoki R
Department of Pharmacology, Faculty of Dentistry, Osaka University, Japan.
Jpn J Pharmacol. 1989 Aug;50(4):503-6. doi: 10.1254/jjp.50.503.
Substance P-like immunoreactivity (SPLI) and methionine-enkephalin-like immunoreactivity (MELI) were determined in salivary glands from rats by radioimmunoassay. In all salivary glands investigated (submandibular gland, sublingual gland and parotid gland), SPLI and MELI were detected. The amount of both peptides is comparable to or relatively higher than those found in any other peripheral tissue. The level of SPLI showed a tendency to increase following chronic treatment with morphine: the enhancement in the submandibular gland and the sublingual gland was especially remarkable. The level of MELI was decreased, particularly in the submandibular gland.
采用放射免疫分析法测定大鼠唾液腺中的P物质样免疫反应性（SPLI）和甲硫氨酸脑啡肽样免疫反应性（MELI）。在所有被研究的唾液腺（下颌下腺、舌下腺和腮腺）中均检测到了SPLI和MELI。这两种肽的含量与在任何其他外周组织中发现的含量相当或相对更高。长期用吗啡处理后，SPLI水平呈升高趋势：下颌下腺和舌下腺的升高尤为显著。MELI水平降低，尤其是在下颌下腺。
