McMurray J, McFarlane L, Coutie W, Balfour D, Struthers A
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland.
J Cardiovasc Pharmacol. 1989 Aug;14(2):326-30. doi: 10.1097/00005344-198908000-00021.
The effect of atrial natriuretic factor (ANF) 99-126 3 or 10 pmol/kg/min on increase in plasma renin activity (PRA) stimulated by a 30-min infusion of prostaglandin E2 (PGE2) 80 ng/kg/min was studied in healthy salt-replete male volunteers. PGE2 increased PRA to approximately 230% of basal levels (p less than 0.001). Concomitant infusion of ANF 3 pmol/kg/min significantly attenuated this rise in PRA to approximately 130% of baseline values (p = 0.02, n = 10). A quantitatively similar effect was observed with ANF 10 pmol/kg/min (n = 5). We suggest, in light of previous findings, that this inhibitory effect of ANF probably represents a nonspecific action rather than a specific effect of ANF on PGE2-mediated increases in PRA.
在健康、钠摄入充足的男性志愿者中，研究了心房利钠因子（ANF）99 - 126以3或10 pmol/kg/min的剂量对由80 ng/kg/min的前列腺素E2（PGE2）输注30分钟所刺激的血浆肾素活性（PRA）升高的影响。PGE2使PRA升高至基础水平的约230%（p < 0.001）。同时输注3 pmol/kg/min的ANF可使PRA的这种升高显著减弱至基线值的约130%（p = 0.02，n = 10）。10 pmol/kg/min的ANF也观察到了类似的定量效应（n = 5）。根据先前的研究结果，我们认为，ANF的这种抑制作用可能代表一种非特异性作用，而非ANF对PGE2介导的PRA升高的特异性作用。
