Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain; Department of Biochemistry and Microbiology, University of Victoria, British Columbia, V8W 3P6, Canada.
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain.
Trends Mol Med. 2014 Sep;20(9):487-98. doi: 10.1016/j.molmed.2014.03.004. Epub 2014 Apr 21.
Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional characterization. It is now becoming apparent that the intrinsic highly disordered nature of MeCP2, which is amenable to a plethora of post-translational modifications (PTMs), allows it to recognize a large number of protein interacting partners, including histones. MeCP2 is highly abundant in the brain and it is an important component of neuronal chromatin; nevertheless, the organization and implications of its involvement in terms of DNA methylation binding dependence and effects on transcription are still not well understood. Recent results have shown that MeCP2 plays an important role in brain development, aging, and in neurological disorders.
自发现其在雷特综合征中的基本作用以来，甲基化 CpG 结合蛋白 2（MeCP2）一直是生化和功能特征详尽分析的焦点。现在，越来越明显的是，MeCP2 固有的高度无序性质使其易于发生多种翻译后修饰（PTMs），从而使其能够识别大量与蛋白质相互作用的伴侣，包括组蛋白。MeCP2 在大脑中含量丰富，是神经元染色质的重要组成部分；然而，其在 DNA 甲基化结合依赖性和对转录的影响方面的参与的组织和意义仍未得到很好的理解。最近的研究结果表明，MeCP2 在大脑发育、衰老和神经疾病中发挥着重要作用。
