Department of Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany.
Cells. 2020 Apr 3;9(4):878. doi: 10.3390/cells9040878.
Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.
甲基化 CpG 结合蛋白 2（MeCP2）是一种多功能的表观遗传读码器，在转录调控和染色质结构中发挥作用，与人类的雷特综合征有关。在这里，我们重点介绍其异构体和功能结构域、相互作用、在雷特患者中发现的修饰和突变。最后，我们讨论这些特性如何调节和介导 MeCP2 协调染色质区室化和更高阶基因组结构的能力。
