[An association study of six-transmembrane protein of prostate 2 gene with metabolic index and tumour necrosis factor in Uygur population].

OBJECTIVE

To explore the relationship between genetic polymorphisms of six-transmembrane protein of prostate 2 (STAMP2) and metabolic index, TNFα in Xinjiang Uygur population.

METHODS

STAMP2 gene functional regions were sequenced in Uygur Xinjiang population diagnosed as metabolic syndrome. Patients were divided into the following three groups by their TNFα concentration: the high level group (TNFα ≥ 7.95 µg/L, n = 313), the moderate level group (TNFα >5.34- < 7.95 µg/L, n = 268) and the low level group ( ≤ 5.34 µg/L, n = 313) . The selected representative variations were genotyped by TaqMan-PCR in 894 Uygur individuals. The association of the genetic variations of STAMP2 gene with metabolic index and TNFα was analyzed.

RESULTS

Three representative variations were genotyped, including rs8122, rs1981529 and rs34741656. The genotype distribution and allele frequencies of rs8122 and rs1981529 were statistically different among the three groups (P < 0.05), while no difference was observed with rs34741656 (P > 0.05). By ANOVA analysis, statistical difference was showed between the rs1981529 polymorphism AA and AG in the concentration of TNFα (P < 0.05) . None of the polymorphisms was significantly associated with TC, HDL-C, LDL-C and TG (P > 0.05).

CONCLUSION

Two STAMP2 gene polymorphisms, rs8122 and rs1981529 are associated with the concentration of TNFα in Xinjiang Uygur population.