Imamoglu Serhat, Kaya Vedat, Oral Deniz, Perente Irfan, Basarir Berna, Yilmaz Omer Faruk
From the Eye Clinic (Imamoglu), Haydarpasa Numune Education and Research Hospital, a private practice (Kaya), the Department of Ophthalmology (Oral), Faculty of Medicine, Yeditepe University, and Beyoglu Eye Training and Research Hospital (Perente, Basarir, Yilmaz), Istanbul, Turkey.
From the Eye Clinic (Imamoglu), Haydarpasa Numune Education and Research Hospital, a private practice (Kaya), the Department of Ophthalmology (Oral), Faculty of Medicine, Yeditepe University, and Beyoglu Eye Training and Research Hospital (Perente, Basarir, Yilmaz), Istanbul, Turkey.
J Cataract Refract Surg. 2014 May;40(5):785-92. doi: 10.1016/j.jcrs.2013.10.042.
To assess the efficacy and safety of corneal wavefront-guided custom laser in situ keratomileusis (LASIK) to correct refractive errors and higher-order aberrations (HOAs) after penetrating keratoplasty (PKP).
Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
Noncomparative case series.
The study comprised consecutive patients who were unable to tolerate spectacles or contact lenses for the correction of anisometropia after PKP and had corneal wavefront-guided custom LASIK. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, manifest refraction spherical equivalent (MRSE), and corneal HOAs were recorded before and after LASIK.
The study evaluated 11 eyes (10 patients). The mean follow-up after LASIK was 24.3 months ± 11.7 (SD) (range 9 to 36 months). The mean MRSE was -2.97 ± 1.66 diopters (D) (range -0.50 to -5.38 D) preoperatively and -0.88 ± 0.96 D (range -2.75 to 0.5 D) postoperatively. The mean total higher-order root mean square (RMS) was 4.65 ± 1.14 μm (range 2.26 to 5.94 μm) preoperatively and 2.71 ± 1.31 μm (range 1.22 to 5.33 μm) postoperatively. Postoperatively, the UDVA improved in 7 eyes and remained unchanged in 4 eyes. The CDVA improved in all eyes postoperatively even cases in which the attempted astigmatic correction was not totally achieved.
Corneal wavefront-guided custom LASIK after PKP did not totally correct both refractive errors and HOAs because of the high volume of laser ablation required and inadequate corneal stromal thickness.
评估角膜波前引导的个体化准分子原位角膜磨镶术（LASIK）在穿透性角膜移植术（PKP）后矫正屈光不正和高阶像差（HOA）的有效性和安全性。
土耳其伊斯坦布尔贝伊奥卢眼科培训与研究医院。
非对照病例系列。
该研究纳入了连续的PKP术后因不能耐受眼镜或隐形眼镜矫正屈光参差而接受角膜波前引导的个体化LASIK的患者。记录LASIK术前和术后的未矫正远视力（UDVA）、矫正远视力（CDVA）、明显屈光不正球镜等效度（MRSE）和角膜HOA。
该研究评估了11只眼（10例患者）。LASIK术后平均随访时间为24.3个月±11.7（标准差）（范围9至36个月）。术前平均MRSE为-2.97±1.66屈光度（D）（范围-0.50至-5.38 D），术后为-0.88±0.96 D（范围-2.75至0.5 D）。术前平均总高阶均方根（RMS）为4.65±1.14μm（范围2.26至5.94μm），术后为2.71±1.31μm（范围1.22至5.33μm）。术后，7只眼的UDVA提高，4只眼保持不变。所有眼的CDVA术后均有改善，即使在散光矫正未完全成功的病例中也是如此。
由于所需激光消融量大且角膜基质厚度不足，PKP术后角膜波前引导的个体化LASIK不能完全矫正屈光不正和HOA。
