血清抗苗勒管激素水平在高雄激素血症状态鉴别诊断中的应用

Serum AMH levels in the differential diagnosis of hyperandrogenemic conditions.

作者信息

Tuten Abdullah, Sahmay Sezai, Oncul Mahmut, Acikgoz Abdullah Serdar, Imamoglu Metehan, Gurleyen Hazel Cagin, Senturk Mehmet Levent

机构信息

Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:121-5. doi: 10.1016/j.ejogrb.2014.03.016. Epub 2014 Apr 2.

DOI:10.1016/j.ejogrb.2014.03.016

PMID:24768424

Abstract

OBJECTIVE

To investigate the diagnostic potential of anti-Müllerian hormone (AMH) in the differential diagnosis of various hyperandrogenemic conditions.

STUDY DESIGN

Among 2241 consecutive women of reproductive age who were seen at a tertiary care university hospital with complaints of acne, hirsutism, androgenetic alopecia, and menstrual dysfunction (oligomenorrhea and/or amenorrhea), 107 patients with serum 17α-hydroxyprogesterone (17α-OHP) levels higher than 2 ng/ml were recruited for this study. An ACTH stimulation test was performed, and basal serum hormonal parameters and AMH levels were measured for all patients.

RESULTS

25 patients were diagnosed with late-onset congenital adrenal hyperplasia (LOCAH), and 59 patients with polycystic ovary syndrome (PCOS) had significantly higher serum AMH levels than all other groups.

CONCLUSION

Among hyperandrogenemic patients with serum 17α-OHP levels >2 ng/ml, serum AMH levels might be introduced as a marker to be utilized clinically in the differential diagnosis of hyperandrogenemic patients, especially for identifying patients with PCOS.

摘要

目的

探讨抗苗勒管激素（AMH）在各种高雄激素血症疾病鉴别诊断中的诊断潜力。

研究设计

在一所三级医疗大学医院就诊的2241例连续育龄女性中，她们主诉有痤疮、多毛症、雄激素性脱发和月经功能障碍（月经过少和/或闭经），本研究招募了107例血清17α-羟孕酮（17α-OHP）水平高于2 ng/ml的患者。对所有患者进行促肾上腺皮质激素（ACTH）刺激试验，并测量基础血清激素参数和AMH水平。