磷脂酰肌醇-4,5-二磷酸：HIV-1舞蹈中肌动蛋白适配蛋白的编排者

Rocha-Perugini Vera, Gordon-Alonso Mónica, Sánchez-Madrid Francisco

Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria de la Princesa, Madrid, Spain; Vascular Biology and Inflammation Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.

Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria de la Princesa, Madrid, Spain.

Trends Microbiol. 2014 Jul;22(7):379-88. doi: 10.1016/j.tim.2014.03.009. Epub 2014 Apr 23.

The actin cytoskeleton plays a key role during the replication cycle of human immunodeficiency virus-1 (HIV-1). HIV-1 infection is affected by cellular proteins that influence the clustering of viral receptors or the subcortical actin cytoskeleton. Several of these actin-adaptor proteins are controlled by the second messenger phosphatidylinositol 4,5-biphosphate (PIP2), an important regulator of actin organization. PIP2 production is induced by HIV-1 attachment and facilitates viral infection. However, the importance of PIP2 in regulating cytoskeletal proteins and thus HIV-1 infection has been overlooked. This review examines recent reports describing the roles played by actin-adaptor proteins during HIV-1 infection of CD4+ T cells, highlighting the influence of the signaling lipid PIP2 in this process.

肌动蛋白细胞骨架在人类免疫缺陷病毒1型（HIV-1）的复制周期中起着关键作用。HIV-1感染受到影响病毒受体聚集或皮层下肌动蛋白细胞骨架的细胞蛋白的影响。这些肌动蛋白衔接蛋白中有几种受第二信使磷脂酰肌醇4,5-二磷酸（PIP2）控制，PIP2是肌动蛋白组织的重要调节因子。HIV-1附着可诱导PIP2产生，并促进病毒感染。然而，PIP2在调节细胞骨架蛋白以及HIV-1感染中的重要性一直被忽视。本综述探讨了最近描述肌动蛋白衔接蛋白在CD4+T细胞HIV-1感染过程中所起作用的报告，强调了信号脂质PIP2在此过程中的影响。