Department of Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
Exp Mol Pathol. 2014 Jun;96(3):400-4. doi: 10.1016/j.yexmp.2014.04.005. Epub 2014 Apr 21.
We present a unique case of a 26 year-old female non-smoker who expired following treatment for presumed pneumonias. At autopsy, lepidic predominant adenocarcinoma with aerogenous spread of mucin without evidence of invasion, a rare diagnosis that previously would have fallen under the umbrella of "bronchioloalveolar carcinoma," was found. Histopathology showed mucin-secreting neoplastic cells lining the alveolar walls, as well as exfoliated and dense aggregates of mucinous debris filling the alveoli. The immediate cause of death was respiratory failure, most likely due to the significant amount of tumor-produced mucin that filled the alveolar spaces, which literally drowned the patient.
我们呈现了一个独特的病例，一位 26 岁的不吸烟女性，在疑似肺炎的治疗后死亡。尸检时，发现以鳞屑为主的腺癌，伴有黏液的气源性播散，无侵袭证据，这是一种罕见的诊断，以前可能属于“细支气管肺泡癌”的范畴。组织病理学显示，黏液分泌性肿瘤细胞排列在肺泡壁上，肺泡内充满脱落的和密集的黏液碎片。直接死因是呼吸衰竭，很可能是由于大量肿瘤产生的黏液充满了肺泡腔，导致患者实际上被“淹死”。
