糙皮侧耳多糖组分对艾氏腹水癌和肉瘤 180 的抗肿瘤活性。
Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180.
机构信息
Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
出版信息
Int J Biol Macromol. 2014 Jul;68:72-7. doi: 10.1016/j.ijbiomac.2014.04.033. Epub 2014 Apr 24.
The medicinal properties of fungi of the genus Pleurotus have attracted great interest due to their therapeutic properties. Polysaccharides synthesized by Pleurotus, including the β-glucans are considered the main responsible for its therapeutic properties. This study aimed to evaluate the efficacy of polysaccharidic fractions extracted from mycelial biomass of Pleurotus ostreatus DSM 1833 in inhibiting the development of Ehrlich Tumor (ET) and Sarcoma 180 (S-180). FC, FI and FII fractions provided 60.6, 76.5 and 73.6% of ET inhibition, respectively (mean value of about 70%) while FS, FIII-1 and FIII-2 showed no inhibition against ET. FII and FIII-2 resulted in 85.6 and 93.6% (mean value of about 90%) while FIII-1, FC and FS resulted in 54.1 and 0%, respectively, of S-180 inhibition. The yields of the fractions FS, FI, FII, FIII-1 and FIII-2 obtained from P. ostreatus mycelial biomass were 11.6, 1.3, 0.4, 0.65 and 0.35%, respectively. FII fraction (30mg/kg) apparently had no toxic effect on healthy animals, since no difference between the body weights of animals in substance control (SC) and negative control (NC) groups was observed.
由于真菌的药用特性，其引起了人们极大的兴趣。平菇合成的多糖，包括β-葡聚糖，被认为是其具有治疗特性的主要原因。本研究旨在评估从糙皮侧耳菌丝体生物量中提取的多糖级分对抑制艾氏腹水瘤（ET）和肉瘤 180（S-180）发展的功效。FC、FI 和 FII 级分分别提供了 60.6%、76.5%和 73.6%的 ET 抑制率（平均值约为 70%），而 FS、FIII-1 和 FIII-2 对 ET 没有抑制作用。FII 和 FIII-2 导致 85.6%和 93.6%（平均值约为 90%），而 FIII-1、FC 和 FS 导致 54.1%和 0%的 S-180 抑制。从糙皮侧耳菌丝体生物量中获得的 FS、FI、FII、FIII-1 和 FIII-2 级分的产率分别为 11.6%、1.3%、0.4%、0.65%和 0.35%。FII 级分（30mg/kg）显然对健康动物没有毒性作用，因为在物质对照（SC）和阴性对照（NC）组中，动物的体重没有差异。
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