Harwig Alex, Das Atze T, Berkhout Ben
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Curr Opin Virol. 2014 Aug;7:47-54. doi: 10.1016/j.coviro.2014.03.013. Epub 2014 Apr 23.
Eukaryotic cells and several DNA viruses encode miRNAs to regulate the expression of specific target genes. It has been controversial whether RNA viruses can encode such miRNAs as miRNA excision may lead to cleavage of the viral RNA genome. We will focus on the retrovirus family, HIV-1 in particular, and discuss the production of virus-encoded miRNAs and their putative function in the viral replication cycle. An intricate scenario of multi-layer virus-host interactions becomes apparent with small RNAs as the regulatory molecules.
真核细胞和几种DNA病毒编码微小RNA（miRNA）来调控特定靶基因的表达。RNA病毒是否能够编码此类miRNA一直存在争议，因为miRNA的切除可能导致病毒RNA基因组的切割。我们将聚焦于逆转录病毒家族，尤其是HIV-1，并讨论病毒编码的miRNA的产生及其在病毒复制周期中的假定功能。随着小RNA作为调控分子，多层病毒-宿主相互作用的复杂情况变得明显。
