Moynihan Patrick J, Sychantha David, Clarke Anthony J
Department of Molecular & Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Department of Molecular & Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Bioorg Chem. 2014 Jun;54:44-50. doi: 10.1016/j.bioorg.2014.03.010. Epub 2014 Apr 8.
Post-synthetic modification of the bacterial cell wall represents an important strategy for pathogenic bacteria to evade innate immunity and control autolysins. Modifications to the glycan backbone of peptidoglycan are generally restricted to the C-6 hydroxyl and C-3 amino moieties, with the most common being acetylation and deacetylation. In this review we discuss the pathways for O-acetylation, de-O-acetylation and N-deacetylation with an emphasis on the chemical-biological approaches used in their investigation. The current challenges in the field and the prospects of targeting these systems with novel therapeutics are also explored.
细菌细胞壁的合成后修饰是病原菌逃避天然免疫和控制自溶素的重要策略。肽聚糖聚糖骨架的修饰通常局限于C-6羟基和C-3氨基部分，最常见的是乙酰化和脱乙酰化。在本综述中，我们讨论了O-乙酰化、去O-乙酰化和N-脱乙酰化的途径，重点是在其研究中使用的化学生物学方法。还探讨了该领域当前面临的挑战以及用新型疗法靶向这些系统的前景。
