Advanced Medical Research Institute of Canada, Sudbury, ON, Canada P3E 5J1.
Advanced Medical Research Institute of Canada, Sudbury, ON, Canada P3E 5J1.
Curr Opin Immunol. 2014 Aug;29:38-42. doi: 10.1016/j.coi.2014.03.008. Epub 2014 Apr 25.
Aging is associated with a decline in the normal function of the immune system, both cellular and humoral, which often leads to a state of 'immunosenescence'. It is necessary that we understand the fundamental cellular and molecular basis of immune senescence and immune responsiveness to prevent age-related diseases, such as viral and bacterial infections, in order to develop appropriate preventative and novel therapeutic measures. Vaccination has been a highly effective prophylactic in protecting vulnerable populations worldwide from many pathogens. Novel vaccine research to enhance protection against these diseases remains a global area of innovation and improvement. This review discusses the impact of immune senescence on the response to influenza vaccines, and the recent progress in translating the knowledge into developing effective influenza vaccines for the elderly to promote healthy aging.
衰老是与细胞和体液免疫的正常功能下降相关的，这通常会导致“免疫衰老”状态。我们有必要了解免疫衰老和免疫反应的基本细胞和分子基础，以预防与年龄相关的疾病，如病毒和细菌感染，从而制定适当的预防和新型治疗措施。疫苗接种一直是保护全世界易受感染人群免受许多病原体侵害的一种非常有效的预防措施。提高对这些疾病的保护作用的新型疫苗研究仍然是全球创新和改进的一个领域。本综述讨论了免疫衰老对流感疫苗反应的影响，以及将这一知识转化为开发针对老年人的有效流感疫苗以促进健康衰老的最新进展。
