Li Sha, Guo Yuan-Lin, Xu Rui-Xia, Zhang Yan, Zhu Cheng-Gang, Sun Jing, Qing Ping, Wu Na-Qiong, Jiang Li-Xin, Li Jian-Jun
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China.
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China.
Atherosclerosis. 2014 Jun;234(2):441-5. doi: 10.1016/j.atherosclerosis.2014.04.001. Epub 2014 Apr 14.
Recent studies have suggested that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with atherosclerosis and plays a potential role in inflammation. However, the correlation between PCSK9 and white blood cell count (WBCC) has not yet been assessed. The objective of the present study was to examine the association of the WBCC and its subset counts with plasma PCSK9 levels in patients with stable coronary artery disease (CAD).
In this cross-sectional study, a total of 251 consecutive, stable CAD patients who were not treated with lipid-lowering drugs were enrolled at our center between October 2012 and October 2013. The baseline clinical characteristics were collected, and the plasma PCSK9 levels were determined using ELISA. The associations of plasma PCSK9 levels with the WBCC and its subsets were investigated.
In the overall population, plasma PCSK9 levels were positively associated with the WBCC (r = 0.167, p = 0.008). Multivariable regression analysis revealed that the plasma PCSK9 levels were significantly and independently associated with the WBCC (β = 0.217, p < 0.001) and its subsets (neutrophil β = 0.152, p < 0.05; lymphocyte β = 0.241, p < 0.001). However, the relationships between PCSK9 and WBCC and its subsets remained significant in men (WBCC r = 0.234, p = 0.001; neutrophil r = 0.181, p = 0.014; lymphocyte r = 0.226, p = 0.002) but were not significant in women when the analysis was performed based on gender.
These data demonstrate that the plasma PCSK9 levels are independently associated with the WBCC and its subsets, suggesting a potential interaction between PCSK9 and chronic inflammation in patients with CAD.
近期研究表明，前蛋白转化酶枯草溶菌素/克新9型（PCSK9）与动脉粥样硬化相关，且在炎症中发挥潜在作用。然而，PCSK9与白细胞计数（WBCC）之间的相关性尚未得到评估。本研究的目的是探讨稳定型冠状动脉疾病（CAD）患者的WBCC及其亚群计数与血浆PCSK9水平之间的关联。
在这项横断面研究中，2012年10月至2013年10月期间，我们中心共纳入了251例未接受降脂药物治疗的连续稳定CAD患者。收集基线临床特征，并使用酶联免疫吸附测定法（ELISA）测定血浆PCSK9水平。研究血浆PCSK9水平与WBCC及其亚群的关联。
在总体人群中，血浆PCSK9水平与WBCC呈正相关（r = 0.167，p = 0.008）。多变量回归分析显示，血浆PCSK9水平与WBCC（β = 0.217，p < 0.001）及其亚群（中性粒细胞β = 0.152，p < 0.05；淋巴细胞β = 0.241，p < 0.001）显著且独立相关。然而，基于性别进行分析时，PCSK9与WBCC及其亚群之间的关系在男性中仍然显著（WBCC r = 0.234，p = 0.001；中性粒细胞r = 0.181，p = 0.014；淋巴细胞r = 0.226，p = 0.002），但在女性中不显著。
这些数据表明，血浆PCSK9水平与WBCC及其亚群独立相关，提示CAD患者中PCSK9与慢性炎症之间可能存在相互作用。
