Hashiba Y, Ishikawa N, Sumita T, Takagi K, Hidaka H, Satake T
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Am Rev Respir Dis. 1989 Sep;140(3):652-8. doi: 10.1164/ajrccm/140.3.652.
This study was undertaken to evaluate the role of vagal nerves in the development of neurogenic pulmonary edema. We injected fibrinogen and thrombin into the cisterna magna of rats, a model of neurogenic pulmonary edema. When the vagal nerves were left intact, pulmonary edema occurred (fibrin-induced pulmonary edema) at a rate of 33%. Vagotomy at the midcervical portion increased the incidence of pulmonary edema to a rate of 100%, whereas pretreatment with atropine did not affect the incidence. These results suggested that vagal afferent nerves or nonadrenergic-noncholinergic efferent nerves played an important role in inhibiting the development of fibrin-induced pulmonary edema. Furthermore, in vagotomized and vagal nerve-intact rats pretreated with capsaicin, the incidence of pulmonary edema was 100%. Pretreatment with a substance P antagonist, [D-Pro2, D-Trp7,9]-SP, also increased the incidence to 100% in the vagal nerve-intact rats. On the other hand, intravenous administration of some neuropeptides that may be released from the capsaicin-sensitive nerves (e.g., substance P or calcitonin gene-related peptide) inhibited the development of pulmonary edema in vagotomized rats. We concluded that the vagal capsaicin-sensitive nerves exerted an inhibitory effect on the development of fibrin-induced pulmonary edema.
本研究旨在评估迷走神经在神经源性肺水肿发生发展中的作用。我们将纤维蛋白原和凝血酶注入大鼠脑池，构建神经源性肺水肿模型。当迷走神经保持完整时，肺水肿（纤维蛋白诱导的肺水肿）发生率为33%。在颈中部进行迷走神经切断术可使肺水肿发生率增至100%，而用阿托品预处理并不影响发生率。这些结果表明，迷走传入神经或非肾上腺素能-非胆碱能传出神经在抑制纤维蛋白诱导的肺水肿发生发展中起重要作用。此外，在用辣椒素预处理的迷走神经切断和迷走神经完整的大鼠中，肺水肿发生率为100%。用P物质拮抗剂[D-脯氨酸2，D-色氨酸7，9]-P预处理也使迷走神经完整大鼠的肺水肿发生率增至100%。另一方面，静脉注射一些可能从辣椒素敏感神经释放的神经肽（如P物质或降钙素基因相关肽）可抑制迷走神经切断大鼠肺水肿的发生发展。我们得出结论，迷走神经的辣椒素敏感神经对纤维蛋白诱导的肺水肿发生发展具有抑制作用。
