Akune Toru
Department of Clinical Motor System Medicine, Graduate School of Medicine, University of Tokyo, Japan.
Clin Calcium. 2014 May;24(5):695-701.
Although a large number of studies have been made to identify genetic loci associated with osteoarthritis (OA), there are only a few that have been reported to be associated with OA in many regions and countries. One of the reasons for the lack of success may be small effect sizes. A sufficiently large sample size is required for the genetic epidemiology on OA to elucidate genetic influence regarding the occurrence and progression.
尽管已经开展了大量研究来确定与骨关节炎（OA）相关的基因位点，但据报道，在许多地区和国家中，只有少数基因位点与OA相关。缺乏成功的原因之一可能是效应量较小。骨关节炎的遗传流行病学需要足够大的样本量，以阐明基因对其发生和进展的影响。
