Pluronics suppress association of low-density lipoproteins inducing atherogenesis.
作者信息
Mel'nichenko A A, Aksenov D V, Panasenko O M, Yaroslavov A A, Sobenin I A, Orehov A N
机构信息
Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia,
出版信息
Bull Exp Biol Med. 2014 Mar;156(5):631-4. doi: 10.1007/s10517-014-2412-5. Epub 2014 Mar 25.
PMID:24770745
Abstract
We studied the effect of pluronics P85, L61, and F68 with different hydrophilic-lipophilic characteristics on association of LDL. It was found that pluronics with pronounced hydrophobic properties (P85 and L61) in concentrations close to or surpassing the critical concentration of micelle formation inhibited LDL association, while hydrophilic pluronic F68 in all concentrations had no effect on LDL association.
摘要
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