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Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

作者信息

Ivy G O, Kitani K, Ihara Y

机构信息

Department of Psychology, University of Toronto, Scarborough, Ont, Canada.

出版信息

Brain Res. 1989 Oct 2;498(2):360-5. doi: 10.1016/0006-8993(89)91117-7.

DOI:10.1016/0006-8993(89)91117-7
PMID:2477115
Abstract

Rats received intraventricular infusion of leupeptin or saline and brain sections were immunostained with antibodies to tau (anti-HFoPHF) or ubiquitin. Results were compared with immunostaining on normal aged rat brains and Alzheimer's disease (AD) brains. Both antibodies stained Purkinje cell perikarya and dendrites of leupeptin (but not saline)-treated and aged rat brains, as well as senile plaque neurites and neurofibrillary tangles in AD brains. The results are consistent with the hypothesis that paired helical filament (PHF) formation involves defective protein degradation.

摘要

相似文献

1
Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?
Brain Res. 1989 Oct 2;498(2):360-5. doi: 10.1016/0006-8993(89)91117-7.
2
Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease.在阿尔茨海默病的神经原纤维病理中，tau蛋白的异常磷酸化先于泛素化。
Brain Res. 1991 Jan 18;539(1):11-8. doi: 10.1016/0006-8993(91)90681-k.
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[Microtubule-associated protein30 (MAP30) and ubiquitin detected in neurofibrillary tangles of Alzheimer's disease brains].[在阿尔茨海默病大脑神经纤维缠结中检测到的微管相关蛋白30（MAP30）和泛素]
Hunan Yi Ke Da Xue Xue Bao. 1998;23(1):11-3.
4
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.微管相关蛋白tau（tau）是阿尔茨海默病中双螺旋丝的主要抗原成分。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):4044-8. doi: 10.1073/pnas.83.11.4044.
5
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.阿尔茨海默病中的老年斑神经突会积累淀粉样前体蛋白。
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7552-6. doi: 10.1073/pnas.88.17.7552.
6
Tau protein immunoreactivity in dementia of the Alzheimer type: II. Electron microscopy and pathogenetic implications. Effects of fixation on the morphology of the Alzheimer's abnormal filaments.阿尔茨海默型痴呆中的tau蛋白免疫反应性：II. 电子显微镜检查及发病机制意义。固定对阿尔茨海默病异常细丝形态的影响。
Lab Invest. 1989 Mar;60(3):375-89.
7
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.单克隆神经丝抗体对阿尔茨海默病配对螺旋丝的识别是由于与tau蛋白发生交叉反应。
Proc Natl Acad Sci U S A. 1987 May;84(10):3415-9. doi: 10.1073/pnas.84.10.3415.
8
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.阿尔茨海默病细胞骨架病理学中微管相关蛋白tau（tau）的异常磷酸化。
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4913-7. doi: 10.1073/pnas.83.13.4913.
9
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
Proc Natl Acad Sci U S A. 1987 May;84(9):3033-6. doi: 10.1073/pnas.84.9.3033.
10
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).人类大脑中神经原纤维病变丰富的区域，其具有结合能力的tau蛋白水平会选择性降低，且异常tau异构体（A68蛋白）会积累。
Lab Invest. 1992 Feb;66(2):212-22.

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The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review.阿尔茨海默病发病机制中神经元的内体-溶酶体系统：综述
Neurochem Res. 2000 Oct;25(9-10):1161-72. doi: 10.1023/a:1007675508413.
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Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.蛋白酶抑制剂与β-淀粉样蛋白共同输注会导致大鼠大脑中沉积增加和毒性增强。
J Neurosci. 1998 Oct 15;18(20):8311-21. doi: 10.1523/JNEUROSCI.18-20-08311.1998.
5
Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus.组织蛋白酶B和L的抑制会导致溶酶体增殖并在海马体中形成巨神经突。
J Neurosci. 1997 Jun 1;17(11):4006-21. doi: 10.1523/JNEUROSCI.17-11-04006.1997.
6
Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.
Acta Neuropathol. 1995;89(1):8-16. doi: 10.1007/BF00294253.
7
Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization.人类和实验性营养不良性轴突中的淀粉样前体蛋白和泛素表位。超微结构定位。
Am J Pathol. 1994 Apr;144(4):702-10.
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Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease.营养不良性轴突中的淀粉样前体蛋白和泛素免疫反应并非阿尔茨海默病所特有。
Am J Pathol. 1991 Sep;139(3):485-9.
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Amyloid enhancing factor activity is associated with ubiquitin.
Virchows Arch A Pathol Anat Histopathol. 1992;420(2):139-48. doi: 10.1007/BF02358805.