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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

作者信息

Perry G, Friedman R, Shaw G, Chau V

出版信息

Proc Natl Acad Sci U S A. 1987 May;84(9):3033-6. doi: 10.1073/pnas.84.9.3033.

DOI:10.1073/pnas.84.9.3033
PMID:3033674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC304795/
Abstract

Neurofibrillary tangles (NFT) and neurites associated with senile plaques (SP) in Alzheimer disease-affected brain tissues were specifically immunostained with affinity-purified antibody preparations directed against ubiquitin. In addition, a class of neurites seen in brain regions containing NFT and SP were also specifically stained. Cross-reactivity of the ubiquitin antisera for tau protein, neurofilament proteins, and high molecular weight microtubule-associated proteins (MAPs) were ruled out by (i) the inability of the ubiquitin antisera to stain these proteins in immunoblotting experiments and (ii) the inability of tau, neurofilament, and MAP preparations, when preincubated with the ubiquitin antisera, to inhibit the selective neurofibrillar staining observed. Our results are consistent with the suggestion that ubiquitin is covalently associated with the insoluble neurofibrillary material of NFT and SP. We propose that the ubiquitin-mediated degradative pathway may be ineffective in removing these fibrillar structures in Alzheimer disease brain.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/b696857492db/pnas00274-0480-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/2668d529fac4/pnas00274-0479-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/5077c1c532f6/pnas00274-0480-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/d0a95b69f430/pnas00274-0480-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/29e489f1a6df/pnas00274-0480-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/b4208eae2080/pnas00274-0480-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/d2df26c6c52b/pnas00274-0480-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/b696857492db/pnas00274-0480-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/2668d529fac4/pnas00274-0479-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/5077c1c532f6/pnas00274-0480-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/d0a95b69f430/pnas00274-0480-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/29e489f1a6df/pnas00274-0480-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/b4208eae2080/pnas00274-0480-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/d2df26c6c52b/pnas00274-0480-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/304795/b696857492db/pnas00274-0480-f.jpg

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1
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
Proc Natl Acad Sci U S A. 1987 May;84(9):3033-6. doi: 10.1073/pnas.84.9.3033.
2
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Alzheimer paired helical filaments: cross-reacting polypeptide/s normally present in brain.阿尔茨海默病双螺旋丝：脑中通常存在的交叉反应性多肽。
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本文引用的文献

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Study of the 10-nm-filament fraction isolated during the standard microtubule preparation.标准微管制备过程中分离出的10纳米细丝部分的研究。
Biochem J. 1980 Nov 1;191(2):543-6. doi: 10.1042/bj1910543.
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Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.ATP在蛋白质分解中的推测作用：蛋白质与ATP依赖性蛋白水解多肽的多条链结合。
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Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).
β淀粉样蛋白的丝氨酸磷酸化模拟物形成独特的、非交叉播种的纤维形态。
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Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease.常染色体显性遗传阿尔茨海默病不同阶段的泛素-蛋白酶体系统
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Enhancing of cerebral Abeta clearance by modulation of ABC transporter expression: a review of experimental approaches.通过调节ABC转运蛋白表达增强脑内β-淀粉样蛋白清除：实验方法综述
Front Aging Neurosci. 2024 May 30;16:1368200. doi: 10.3389/fnagi.2024.1368200. eCollection 2024.
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The influence of APOE on the pTau interactome in sporadic Alzheimer's disease.载脂蛋白 E 对散发性阿尔茨海默病中 pTau 相互作用组的影响。
Acta Neuropathol. 2024 May 21;147(1):91. doi: 10.1007/s00401-024-02744-8.
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Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy.阿尔茨海默病：对病理学、分子机制及治疗的见解
Protein Cell. 2025 Feb 1;16(2):83-120. doi: 10.1093/procel/pwae026.
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淀粉样沉积物与淀粉样变性：β-纤维蛋白病变（两部分中的第二部分）
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4
Phosphorylation affects the ability of tau protein to promote microtubule assembly.磷酸化影响tau蛋白促进微管组装的能力。
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Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins.阿尔茨海默病中针对双螺旋丝的抗体不能识别正常脑蛋白。
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Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85.在哺乳动物细胞周期突变体ts85中证实了选择性蛋白质降解对泛素的依赖性。
Cell. 1984 May;37(1):57-66. doi: 10.1016/0092-8674(84)90300-3.
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ATP-dependent degradation of ubiquitin-protein conjugates.泛素 - 蛋白质缀合物的ATP依赖性降解。
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Proc Natl Acad Sci U S A. 1982 Oct;79(19):5857-61. doi: 10.1073/pnas.79.19.5857.
9
Ubiquitin: roles in protein modification and breakdown.泛素：在蛋白质修饰和降解中的作用。
Cell. 1983 Aug;34(1):11-2. doi: 10.1016/0092-8674(83)90131-9.
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Mechanisms of intracellular protein breakdown.细胞内蛋白质降解的机制。
Annu Rev Biochem. 1982;51:335-64. doi: 10.1146/annurev.bi.51.070182.002003.