Mogensen O, Mogensen B, Jakobsen A
Department of Oncology, Aarhus University Hospital, Denmark.
Cancer. 1989 Nov 1;64(9):1867-71. doi: 10.1002/1097-0142(19891101)64:9<1867::aid-cncr2820640919>3.0.co;2-y.
Serum values of alpha 1-acid glucoprotein (alpha 1-AG) were measured by a radial immunodiffusion technique before the primary operation of 60 ovarian tumors and before the second-look laparotomy of 80 ovarian carcinomas. The results were compared with cancer antigen 125 (CA 125) measurements performed in the same samples by a radioimmunoassay or enzymeimmunoassay. The sensitivity and negative predictive value of the alpha 1-AG measurements were low both before the primary operation (37% and 31%, respectively) and the second-look operation (10% and 51%, respectively). Inversely, the CA 125 measurements before the primary operation demonstrated a sensitivity and negative predictive value of 93% and 81%, respectively. In the second-look group the corresponding CA 125 results were 41% and 62%, respectively. The specificity and positive predictive value of alpha 1-AG before the primary and the second-look operation were high and almost identical to those of CA 125 (93%-100%). All patients with increased alpha 1-AG values also had increased CA 125 levels. Alpha 1-AG cannot be distinguished from immunosuppressive acidic protein (IAP) by radial immunodiffusion technique. In conclusion, the alpha 1-AG analyses did not add new information to the CA 125 measurements. The use of alpha 1-AG (or IAP) as a tumor marker in ovarian cancer cannot be recommended.
采用放射免疫扩散技术检测了60例卵巢肿瘤初次手术前及80例卵巢癌二次剖腹探查术前血清α1-酸性糖蛋白（α1-AG）的值。将结果与用放射免疫测定法或酶免疫测定法对相同样本进行的癌抗原125（CA 125）检测结果进行比较。α1-AG检测在初次手术前（分别为37%和31%）和二次探查手术前（分别为10%和51%）的敏感性和阴性预测值均较低。相反，初次手术前CA 125检测的敏感性和阴性预测值分别为93%和81%。在二次探查组中，相应的CA 125结果分别为41%和62%。初次手术和二次探查手术前α1-AG的特异性和阳性预测值较高，且几乎与CA 125相同（93%-100%）。所有α1-AG值升高的患者CA 125水平也升高。放射免疫扩散技术无法区分α1-AG和免疫抑制酸性蛋白（IAP）。总之，α1-AG分析并未为CA 125检测增添新信息。不建议将α1-AG（或IAP）用作卵巢癌的肿瘤标志物。
