Maternal-Child Nursing and Public Health Department of the Nursing School, Nursing School, Federal University of Minas Gerais, (UFMG), 30130-100 Belo Horizonte, MG, Brazil.
Department of Dentistry, Program in Health Sciences, State University of Montes Claros (UNIMONTES), 39401-001Montes Claros, MG, Brazil.
Cardiol Res Pract. 2014;2014:879037. doi: 10.1155/2014/879037. Epub 2014 Feb 13.
Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. Polymorphism identification was performed using PCR-RFLP analysis. Participants with blood pressure ≥ 140/90 mmHg or medication use were considered hypertensive. Frequencies, means, cross-tabulations, and multivariate models were produced to study differences in hypertension prevalence by genotypes. The study includes 470 participants. The frequency of GG polymorphism variant was 10.43%, 46.81% AG, and 42.77% AA. The distribution of hypertension frequency by LEPR genotypes was the following: AA 43.8%, AG 40.4%, and GG 40.8%; there were no significant differences between groups. Comparative analysis which used multivariate Poisson regression adjusted by many potential confounders (age, sex, schooling, smoking, alcohol intake, obesity, and family history of parental obesity) did not modify this result. In this large sample of population-based study, the association of the LEPR Gln223Arg gene polymorphism with hypertension was not observed.
高血压是最重要的心血管代谢危险因素之一，其发病率和死亡率都很高。本研究旨在探讨瘦素受体（LEPR）中的 Gln223Arg 突变是否会影响高血压的患病率。这是一项横断面研究，纳入了年龄≥18 岁的个体。采用 PCR-RFLP 分析进行多态性鉴定。血压≥140/90mmHg 或正在服用降压药的患者被定义为高血压。通过基因型研究高血压的患病率差异，生成了频率、平均值、交叉表和多变量模型。本研究共纳入了 470 名参与者。GG 多态性变异的频率为 10.43%，AG 为 46.81%，AA 为 42.77%。LEPR 基因型的高血压患病率分布如下：AA 为 43.8%，AG 为 40.4%，GG 为 40.8%；各组间无显著差异。使用多元 Poisson 回归校正了许多潜在混杂因素（年龄、性别、教育程度、吸烟、饮酒、肥胖和父母肥胖史）的比较分析并未改变这一结果。在这项基于人群的大型样本研究中，并未观察到 LEPR Gln223Arg 基因多态性与高血压之间存在关联。
