Moreland R Travis, Nguyen Anh-Dao, Ryan Joseph F, Schnitzler Christine E, Koch Bernard J, Siewert Katherine, Wolfsberg Tyra G, Baxevanis Andreas D
Genome Technology Branch, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA.
BMC Genomics. 2014 Apr 28;15:316. doi: 10.1186/1471-2164-15-316.
Mnemiopsis leidyi is a ctenophore native to the coastal waters of the western Atlantic Ocean. A number of studies on Mnemiopsis have led to a better understanding of many key biological processes, and these studies have contributed to the emergence of Mnemiopsis as an important model for evolutionary and developmental studies. Recently, we sequenced, assembled, annotated, and performed a preliminary analysis on the 150-megabase genome of the ctenophore, Mnemiopsis. This sequencing effort has produced the first set of whole-genome sequencing data on any ctenophore species and is amongst the first wave of projects to sequence an animal genome de novo solely using next-generation sequencing technologies.
The Mnemiopsis Genome Project Portal (http://research.nhgri.nih.gov/mnemiopsis/) is intended both as a resource for obtaining genomic information on Mnemiopsis through an intuitive and easy-to-use interface and as a model for developing customized Web portals that enable access to genomic data. The scope of data available through this Portal goes well beyond the sequence data available through GenBank, providing key biological information not available elsewhere, such as pathway and protein domain analyses; it also features a customized genome browser for data visualization.
We expect that the availability of these data will allow investigators to advance their own research projects aimed at understanding phylogenetic diversity and the evolution of proteins that play a fundamental role in metazoan development. The overall approach taken in the development of this Web site can serve as a viable model for disseminating data from whole-genome sequencing projects, framed in a way that best-serves the specific needs of the scientific community.
海胡桃是一种栉水母，原产于西大西洋沿海水域。多项关于海胡桃的研究使人们对许多关键生物学过程有了更深入的了解，这些研究促使海胡桃成为进化与发育研究的重要模型。最近，我们对栉水母海胡桃150兆碱基的基因组进行了测序、组装、注释并开展了初步分析。这项测序工作产生了首个栉水母物种的全基因组测序数据，并且是仅使用新一代测序技术从头测序动物基因组的首批项目之一。
我们预计这些数据的可用性将使研究人员能够推进他们自己旨在了解系统发育多样性以及在后生动物发育中起基本作用的蛋白质进化的研究项目。本网站开发所采用的总体方法可作为传播全基因组测序项目数据的可行范例，其框架能最好地满足科学界的特定需求。
