Yucel Burak, Usta Taner A, Kaya Erdal, Turgut Hurriyet, Ates Ugur
Department of Obstetrics and Gynecology, Acıbadem Hospital, Kayseri, Turkey.
Department of Obstetrics and Gynecology, Bagcilar Training and Research Hospital, Bagcilar, Istanbul, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:126-9. doi: 10.1016/j.ejogrb.2014.03.029. Epub 2014 Apr 8.
We assess follicular reserve changes by follicle count in torsion-detorsion rat model.
30 albino rats were randomly divided into 3 groups: sham group (SG), detorsion after 24-hour torsion group (24hTG) and detorsion after 72-hour torsion group (72hTG). Ovaries were torsioned and fixed. They were untwisted 24 and 72 h later. Oophorectomies were performed at 14th day after detorsion. Tissue damage scoring and follicle counts were evaluated microscopically.
Tissue damage scores (TDSs) were higher in 72hTG and 24hTG compared to SG. In addition, as we increase torsion duration, TDSs also increased. There was no statistically significant difference in follicle numbers (primordial, primary, secondary and tertiary).
Duration of torsion and intensity of ovarian damage do not affect follicular reserve in a rat model. Regardless of their macroscopic appearance, ovaries maintain their follicle reserves after torsion. Thus, surgeons should be reassured and encouraged to untwist torsioned ovaries rather than removing them.
我们通过在扭转-复位大鼠模型中进行卵泡计数来评估卵泡储备的变化。
30只白化大鼠被随机分为3组：假手术组（SG）、扭转24小时后复位组（24hTG）和扭转72小时后复位组（72hTG）。对卵巢进行扭转并固定。分别在24小时和72小时后将其复位。在复位后第14天进行卵巢切除术。通过显微镜评估组织损伤评分和卵泡计数。
与SG组相比，72hTG组和24hTG组的组织损伤评分（TDS）更高。此外，随着扭转持续时间的增加，TDS也增加。卵泡数量（原始卵泡、初级卵泡、次级卵泡和三级卵泡）没有统计学上的显著差异。
在大鼠模型中，扭转持续时间和卵巢损伤强度不影响卵泡储备。无论其宏观外观如何，卵巢在扭转后仍保持其卵泡储备。因此，外科医生应放心并被鼓励对扭转的卵巢进行复位而不是切除。
