Bozkirli Emine D E, Keşkek Sakir Özgur, Kozanoğlu Ilknur, Yücel Ahmet Eftal
Başkent University School of Medicine, Department of Rheumatology, Adana, Turkey.
Clin Exp Rheumatol. 2014 Jul-Aug;32(4 Suppl 84):S49-53. Epub 2014 Apr 28.
Behçet's disease (BD) is a systemic disorder characterised by vasculitis. Endothelial progenitor cells are derived from the bone marrow and contribute to new vessel formation. The aim of this study was to investigate the level of endothelial progenitor cells in BD and BD-associated conditions.
A total of 74 subjects were included in this study, of whom 44 and 30 subjects were patients with BD or healthy subjects, respectively. Endothelial progenitor cells were defined and measured by flow cytometry according to the expression of CD146, CD31 and CD34. We separated BD patients according to the active disease, pathergy test results, thrombosis and gender. MedCalc 12.5 software programme was used for statistical analyses.
The level of endothelial progenitor cells was comparable in patients with BD and healthy subjects (p=0.849). It was also comparable in patients with active or inactive BD (p=0.320). The level of endothelial progenitor cells was higher in patients with thrombosis (p=0.04). There was no statistical significant difference between pathergy positive and negative patients (p=0.969). The level of endothelial progenitor cells was not correlated with age, C-reactive protein, erythrocyte sedimentation rate, white blood cells and disease duration (p>0.05).
The level of endothelial progenitor cells was significantly higher in BD patients with thrombosis. On the other hand, they were not associated with disease activity, pathergy test and other conditions. EPCs may be a useful marker for thrombosis in patients with BD. In our opinion, this is the most expected result in this study.
白塞病（BD）是一种以血管炎为特征的全身性疾病。内皮祖细胞来源于骨髓，有助于新血管形成。本研究的目的是调查BD及BD相关病症中内皮祖细胞的水平。
本研究共纳入74名受试者，其中44名和30名受试者分别为BD患者或健康受试者。根据CD146、CD31和CD34的表达，通过流式细胞术定义并测量内皮祖细胞。我们根据疾病活动情况、针刺反应试验结果、血栓形成情况和性别对白塞病患者进行了分组。使用MedCalc 12.5软件程序进行统计分析。
BD患者和健康受试者的内皮祖细胞水平相当（p = 0.849）。活动期或非活动期BD患者的内皮祖细胞水平也相当（p = 0.320）。血栓形成患者的内皮祖细胞水平较高（p = 0.04）。针刺反应阳性和阴性患者之间无统计学显著差异（p = 0.969）。内皮祖细胞水平与年龄、C反应蛋白、红细胞沉降率、白细胞和病程无关（p>0.05）。
血栓形成的BD患者内皮祖细胞水平显著更高。另一方面，它们与疾病活动、针刺反应试验及其他情况无关。内皮祖细胞可能是BD患者血栓形成的一个有用标志物。在我们看来，这是本研究中最预期的结果。
