Kul Ayhan, Ateş Orhan, Alkan Melikoğlu Meltem, Uğur Mahir, Öztürk Nurinnisa, Erkayhan Gülsüm, Koçer İbrahim
Department of Physical Medicine and Rehabilitation, Medical Faculty of Atatürk University Erzurum, Turkey.
Department of Ophtalmologia, Medical Faculty of Atatürk University Erzurum, Turkey.
Arch Rheumatol. 2017 Mar 24;32(3):197-202. doi: 10.5606/ArchRheumatol.2017.6072. eCollection 2017 Sep.
This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease.
Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects.
Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001).
Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.
本研究旨在探讨活动期白塞病患者血清内脂素、血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）水平之间的关系。
本研究纳入40例活动期白塞病患者（男24例，女16例；平均年龄37.6±8.7岁；年龄范围20至50岁）和40例健康对照者（男22例，女18例；平均年龄38.8±7.9岁；年龄范围21至52岁）。患者组和对照组均由同一位专科医生进行全面的全身及眼科检查。采用酶联免疫吸附测定试剂盒检测所有受试者的内脂素、VEGF和TNF-α水平。
患者组和对照组血清内脂素水平分别为775.2±479.3 ng/mL和275.8±145.8 ng/mL。患者组和对照组VEGF水平分别为1768.2±900.5 pg/mL和980.2±135.3 pg/mL。患者组和对照组TNF-α水平分别为22.4±74.3 pg/mL-1和11.4±16.9 pg/mL-1。患者组和对照组在血清内脂素、VEGF和TNF-α水平方面存在统计学显著差异。患者组血清内脂素与VEGF水平之间存在显著正相关（r=0.630；p<0.001）。此外，患者组血清内脂素与TNF-α水平之间也存在显著正相关（r=0.713；p<0.001）。
血清内脂素水平可能是评估白塞病预后和活动度的一个新标志物。
