Salmaggi A, LaMantia L, Milanese C, Bianchi G, Eoli M, Campi A, Nespolo A
Neurological Institute C. Besta, Milan, Italy.
J Neurol. 1989 Sep;236(6):336-9. doi: 10.1007/BF00314375.
Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.
在多发性硬化症以及其他炎症性和非炎症性神经系统疾病患者中，对脑脊液髓鞘碱性蛋白以及脑脊液和外周血T细胞亚群进行了研究。这些生物学参数已与临床疾病活动相关联。多发性硬化症患者的外周血T细胞亚群未见变化。低脑脊液T8 +细胞仅在多发性硬化症中出现，而高脑脊液T4 +细胞在临床活动期的多发性硬化症和炎症性神经系统疾病中均被检测到。在复发型多发性硬化症患者中，发现脑脊液T4/T8比值与髓鞘碱性蛋白之间存在密切关系。
