Douglas S A, Bowmer C J, Yates M S
Department of Pharmacology, The University, Leeds, UK.
J Pharm Pharmacol. 1989 Aug;41(8):541-4. doi: 10.1111/j.2042-7158.1989.tb06522.x.
Vascular smooth muscle function in rats with glycerol-induced acute renal failure (ARF) was investigated by recording both the contractile responses of portal vein segments and the relaxant responses depressed contractile responses to the alpha 1-agonist methoxamine, the alpha 2-agonist B-HT 920 and to the calcium agonist BAY K 8644 when compared with controls. Both isoprenaline and nitroprusside produced 100% reversal of KCl induced tone in control aortic rings but in rings from rats with ARF complete reversal of of tone could not be obtained with either dilator drug. It is suggested that a defect in mitochondrial function and hence energy supply may account for the diminished ability of vascular preparations from rats with ARF to constrict and relax.
通过记录门静脉段的收缩反应以及与对照组相比，α1-激动剂甲氧明、α2-激动剂B-HT 920和钙激动剂BAY K 8644引起的收缩反应受抑制的舒张反应，研究了甘油诱导的急性肾衰竭（ARF）大鼠的血管平滑肌功能。与对照组相比，异丙肾上腺素和硝普钠在对照主动脉环中可使氯化钾诱导的张力完全逆转，但在ARF大鼠的主动脉环中，两种扩张剂均无法使张力完全逆转。提示线粒体功能缺陷以及由此导致的能量供应不足，可能是ARF大鼠血管制剂收缩和舒张能力下降的原因。
