*Department of Radiation Oncology, University of Florida Health Cancer Center, Gainesville, FL; †BioPowerTech, 4734 Bluegrass Pkwy, Tuscaloosa, AL 35406; ‡Department of Pharmaceutics, University of Florida, College of Pharmacy, University of Florida, Gainesville, FL; §DiaCarta, LLC, Hayward, CA 94545.
Health Phys. 2014 Jun;106(6):704-12. doi: 10.1097/HP.0000000000000095.
The effects of fibroblast growth factors and their potential as broad-spectrum agents to treat and mitigate radiation injury have been studied extensively over the past two decades. This report shows that a peptide mimetic of basic fibroblast growth factor (FGF-P) protects and mitigates against acute radiation syndromes. FGF-P attenuates both sepsis and bleeding in a radiation-induced bone marrow syndrome model and reduces the severity of gastrointestinal and cutaneous syndromes; it should also mitigate combined injuries. FGF-2 and FGF-P induce little or no deleterious inflammation or vascular leakage, which distinguishes them from most other growth factors, angiogenic factors, and cytokines. Although recombinant FGFs have proven safe in several ongoing clinical trials, they are expensive to synthesize, can only be produced in limited quantity, and have limited shelf life. FGF-P mimics the advantageous features of FGF-2 without these disadvantages. This paper shows that FGF-P not only has the potential to be a potent yet safe broad-spectrum medical countermeasure that mitigates acute radiotoxicity but also holds promise for thermal burns, ischemic wound healing, tissue engineering, and stem-cell regeneration.
在过去的二十年中，人们广泛研究了成纤维细胞生长因子的作用及其作为广谱药物治疗和减轻辐射损伤的潜力。本报告表明，碱性成纤维细胞生长因子（FGF-P）的肽模拟物具有保护作用，可以减轻急性辐射综合征。FGF-P 可减轻辐射诱导的骨髓综合征模型中的败血症和出血，并减轻胃肠道和皮肤综合征的严重程度；它还应该减轻联合损伤。FGF-2 和 FGF-P 引起的炎症或血管渗漏很少或没有，这使它们有别于大多数其他生长因子、血管生成因子和细胞因子。尽管几种正在进行的临床试验已经证明重组 FGFs 是安全的，但它们的合成成本很高，只能限量生产，且保质期有限。FGF-P 模拟了 FGF-2 的有利特征，而没有这些缺点。本文表明，FGF-P 不仅有可能成为一种有效的、安全的广谱医疗对策，减轻急性放射毒性，而且在热烧伤、缺血性伤口愈合、组织工程和干细胞再生方面也有很大的潜力。
