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本文引用的文献

1
Radiation and inflammation.辐射与炎症。
Semin Radiat Oncol. 2015 Jan;25(1):4-10. doi: 10.1016/j.semradonc.2014.07.007.
2
Hematopoiesis in 5-fluorouracil-treated adenosine A(3) receptor knock-out mice.5-氟尿嘧啶处理的腺苷A(3)受体基因敲除小鼠的造血作用
Physiol Res. 2015;64(2):255-62. doi: 10.33549/physiolres.932847. Epub 2014 Oct 15.
3
Cyclooxygenase inhibitors: From pharmacology to clinical read-outs.环氧化酶抑制剂：从药理学到临床结果
Biochim Biophys Acta. 2015 Apr;1851(4):422-32. doi: 10.1016/j.bbalip.2014.09.016. Epub 2014 Sep 28.
4
A basic fibroblast growth factor analog for protection and mitigation against acute radiation syndromes.一种碱性成纤维细胞生长因子类似物，用于预防和减轻急性放射综合征。
Health Phys. 2014 Jun;106(6):704-12. doi: 10.1097/HP.0000000000000095.
5
A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation increases survival of lethally irradiated mice.单次给予环氧化酶 2 抑制剂美洛昔康，在辐照后不久给予，可提高致死性辐照小鼠的存活率。
Radiat Res. 2011 Aug;176(2):269-72. doi: 10.1667/rr2614.1. Epub 2011 Jun 10.
6
Inhibition of cyclooxygenase 2 in mice increases production of g-csf and induces radioprotection.抑制小鼠体内的环氧化酶2可增加粒细胞集落刺激因子的产生并诱导辐射防护。
Radiat Res. 2008 Nov;170(5):566-71. doi: 10.1667/RR1387.1.
7
Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy.美洛昔康，一种环氧化酶-2抑制剂，可提高血清G-CSF水平，可能可用作G-CSF治疗的辅助手段。
Physiol Res. 2008;57(2):307-310. doi: 10.33549/physiolres.931237. Epub 2007 May 30.
8
Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice.美洛昔康，一种环氧化酶2抑制剂，可促进γ射线照射小鼠的造血恢复。
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9
A comparison of the local tolerability, safety and efficacy of meloxicam and piroxicam suppositories in patients with osteoarthritis: a single-blind, randomized, multicentre study.美洛昔康与吡罗昔康栓剂治疗骨关节炎患者的局部耐受性、安全性及有效性比较：一项单盲、随机、多中心研究
Curr Med Res Opin. 1995;13(6):343-55. doi: 10.1185/03007999509110494.
10
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.前列腺素合成酶2基因破坏导致小鼠出现严重的肾脏病变。
Cell. 1995 Nov 3;83(3):473-82. doi: 10.1016/0092-8674(95)90125-6.

未治疗或暴露于电离辐射的环氧化酶-2缺陷小鼠的血液学特征

Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice.

作者信息

Hofer M, Hoferová Z, Dušek L, Souček K, Gruzdev A

机构信息

Department of Molecular Cytology and Cytometry, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.

出版信息

Physiol Res. 2017 Sep 22;66(4):673-676. doi: 10.33549/physiolres.933568. Epub 2017 Apr 12.

DOI:10.33549/physiolres.933568
PMID:28406698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6057777/
Abstract

We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.

摘要

我们研究了未接受治疗以及暴露于电离辐射的环氧化酶-2缺陷（COX-2基因敲除）小鼠的造血作用。我们对未接受治疗的COX-2基因敲除雄性小鼠、接受4 Gy剂量γ射线照射的COX-2基因敲除雄性小鼠及其野生型同窝小鼠进行了包含16项参数的复杂血液学分析。在基线时，COX-2缺陷小鼠的造血作用增强，但与野生型相比，COX-2缺陷小鼠在接受照射后造血作用减弱。总之，COX-2基因破坏的抗炎作用在基础条件下对造血起积极作用，但在辐射暴露后则有害。