Department of Orthopedic Surgery, Japanese Red Cross Kyoto Daini Hospital, 355-5 Haruobi-cho, Kamanza, Marutamachi, Kamigyo-ku, Kyoto, 602-8026, Japan,
Arch Osteoporos. 2014;9:179. doi: 10.1007/s11657-014-0179-y. Epub 2014 Apr 29.
Two cases of delayed union that were effectively treated with weekly TPTD administration are described. The effect of this therapy was observed within 4 weeks.
In the first case, a 72-year-old woman underwent osteotomy for the treatment of hallux valgus. Bone union was still not observed 4 months after surgery. Therefore, weekly teriparatide (56.5 mg) injections were administered, resulting in the initiation of bone union within 4 weeks and complete bone union 4 months after the first teriparatide injection. In the second case, a 72-year-old woman underwent open reduction and internal fixation of an olecranon fracture. Bone union was delayed 4 months after surgery; therefore, weekly teriparatide (56.5 mg) injections were started.
The initiation of bone union was slightly evident within 4 weeks, and complete healing was achieved 4 months after the first teriparatide injection. In both cases, no serious teriparatide-related adverse effects were observed.
Weekly teriparatide administration was effective for bone healing and useful for delayed union; moreover, the effect of this therapy showed within 4 weeks.
本文描述了两例采用每周 TPTD 给药治疗有效延迟愈合的病例。这种治疗的效果在 4 周内观察到。
在第一例中，一名 72 岁女性因拇外翻而行截骨术。手术后 4 个月仍未观察到骨愈合。因此，每周给予特立帕肽（56.5mg）注射，在首次特立帕肽注射后 4 周内开始骨愈合，4 个月后完全愈合。在第二例中，一名 72 岁女性因鹰嘴骨折行切开复位内固定术。手术后 4 个月出现骨愈合延迟；因此，开始每周给予特立帕肽（56.5mg）注射。
在 4 周内骨愈合开始略有明显，首次特立帕肽注射后 4 个月完全愈合。在这两例中，均未观察到与特立帕肽相关的严重不良反应。
每周特立帕肽给药对骨愈合有效，可用于治疗延迟愈合；此外，这种治疗的效果在 4 周内显示出来。
