Song Gwan Gyu, Bae Sang-Cheol, Lee Young Ho
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea.
Rheumatol Int. 2014 Nov;34(11):1529-37. doi: 10.1007/s00296-014-3027-x. Epub 2014 Apr 29.
Several studies have examined the effects of tumor necrosis factor receptor (TNFR) 1 +38 A/G and TNFR2 196 M/R polymorphisms on susceptibility to RA and have reported conflicting results. The purpose of this study was to examine whether the TNFR1 +38 A/G and TNFR2 196 M/R polymorphisms are associated with RA susceptibility. We performed a literature search using the Medical Literature Analysis and Retrieval System Online and Embase citation indices, and conducted a meta-analysis to examine the association between the TNFR1 +38 A/G and TNFR2 196 M/R polymorphisms and RA. Our meta-analysis included a total of 13 studies from 11 articles, consisting of 11 studies of the TNFR2 polymorphism (2,092 cases and 1,483 controls), and two studies of the TNFR1 polymorphism (672 cases and 288 controls). The meta-analysis revealed a significant association between the TNFR2 196 RR genotype and RA risk (OR 1.737, 95 % CI 1.275-2.367, P = 4.6 × 10(-5)). Stratification by ethnicity indicated an association between the TNFR2 196 RR genotype and RA in Europeans (OR 2.054, 95 % CI 1.305-3.232, P = 0.002), but not in East Asians (OR 1.596, 95 % CI 0.642-3.971, P = 0.314). Analysis using a homozygote contrast model showed the same pattern for the TNFR2 196 RR genotype in a European and East Asian population. However, no association was found between the TNFR1 +36 A/G polymorphism and RA in a European population. Our meta-analysis demonstrated that the functional TNFR2 196 M/R polymorphism is associated with susceptibility to RA in the European population.
多项研究探讨了肿瘤坏死因子受体（TNFR）1 +38 A/G和TNFR2 196 M/R多态性对类风湿关节炎（RA）易感性的影响，报告结果相互矛盾。本研究旨在探讨TNFR1 +38 A/G和TNFR2 196 M/R多态性是否与RA易感性相关。我们使用医学文献分析和检索系统在线数据库（MEDLINE）及荷兰医学文摘数据库（Embase）的文献索引进行文献检索，并进行荟萃分析以研究TNFR1 +38 A/G和TNFR2 196 M/R多态性与RA之间的关联。我们的荟萃分析共纳入11篇文章中的13项研究，其中包括11项关于TNFR2多态性的研究（2092例患者和1483例对照）以及2项关于TNFR1多态性的研究（672例患者和288例对照）。荟萃分析显示，TNFR2 196 RR基因型与RA风险之间存在显著关联（比值比[OR] 1.737，95%置信区间[CI] 1.275 - 2.367，P = 4.6 × 10⁻⁵）。按种族分层显示，TNFR2 196 RR基因型与欧洲人的RA相关（OR 2.054，95% CI 1.305 - 3.232，P = 0.002），但与东亚人无关（OR 1.596，95% CI 0.642 - 3.971，P = 0.314）。使用纯合子对比模型分析显示，欧洲人和东亚人群中TNFR2 196 RR基因型的情况相同。然而，在欧洲人群中未发现TNFR1 +36 A/G多态性与RA相关。我们的荟萃分析表明，功能性TNFR2 196 M/R多态性与欧洲人群的RA易感性相关。
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