Lee Young Ho, Bae Sang-Cheol, Song Gwan Gyu
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea.
Clin Exp Rheumatol. 2015 Sep-Oct;33(5):647-54. Epub 2015 Aug 27.
The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA).
We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1/NA2 polymorphisms and RA susceptibility.
A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared toFF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis.
Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated with RA in Europeans, but not in Asians.
本研究旨在探讨Fcγ受体（FCGR）基因多态性与类风湿关节炎（RA）易感性之间是否存在关联。
我们对FCGR2A H131R（rs1801274）、FCGR3A F158V（rs396991）和FCGR3B NA1/NA2基因多态性与RA易感性之间的关联进行了荟萃分析。
我们的荟萃分析纳入了14篇文章中报道的共17项研究（4418例RA患者和3560例对照）。在所有研究对象中，荟萃分析表明RA与FCGR2A的R等位基因之间存在关联（OR = 0.877，95% CI = 0.792 - 0.971，p = 0.011）。按种族分层显示，在欧洲人中FCGR2A的R等位基因与RA存在关联（OR = 0.816，95% CI = 0.687 - 0.968，p = 0.020），但在东亚人中无此关联（OR = 0.900，95% CI = 0.778 - 1.040，p = 0.154）。荟萃分析显示，在所有研究对象中RA与FCGR3A的VV基因型与FF基因型相比存在关联（OR = 1.210，95% CI = 1.067 - 1.479，p = 0.006）。按种族分层表明，在欧洲人中FCGR3A的VV基因型与RA相关，与FF基因型相比（OR = 1.350，95% CI = 1.107 - 1.646，p = 0.003），但在东亚人和南亚人中无此关联。在进行荟萃分析时，未观察到RA与FCGR3B基因多态性之间存在关联。
虽然未发现FCGR3B基因多态性与RA易感性之间存在关系，但发现FCGR2A和FCGR3A基因多态性在欧洲人与RA相关，而在亚洲人中无此关联。
