Lopes Marlene, Belo Isabel, Mota Manuel
Center of Biological Engineering, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Biotechnol Prog. 2014 Jul-Aug;30(4):767-75. doi: 10.1002/btpr.1917. Epub 2014 May 8.
In industrial biotechnology, microbial cultures are exposed to different local pressures inside bioreactors. Depending on the microbial species and strains, the increased pressure may have detrimental or beneficial effects on cellular growth and product formation. In this review, the effects of increased air pressure on various microbial cultures growing in bioreactors under moderate total pressure conditions (maximum, 15 bar) will be discussed. Recent data illustrating the diversity of increased air pressure effects at different levels in microbial cells cultivation will be presented, with particular attention to the effects of oxygen and carbon dioxide partial pressures on cellular growth and product formation, and the concomitant effect of oxygen pressure on antioxidant cellular defense mechanisms.
在工业生物技术中，微生物培养物在生物反应器内会受到不同的局部压力。根据微生物的种类和菌株，压力增加可能对细胞生长和产物形成产生有害或有益的影响。在本综述中，将讨论在中等总压力条件下（最大15巴）生物反应器中生长的各种微生物培养物，空气压力增加所产生的影响。将展示近期的数据，这些数据说明了在微生物细胞培养的不同水平上，空气压力增加所产生影响的多样性，尤其关注氧气和二氧化碳分压对细胞生长和产物形成的影响，以及氧气压力对细胞抗氧化防御机制的伴随影响。
