Cheng Tsu-Yao, Wu Ming-Shiang, Lin Jaw-Town, Lin Ming-Tsan, Shun Chia-Tung, Hua Kuo-Tai, Kuo Min-Liang
Laboratory of Molecular and Cellular Toxicology, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan, R.O.C.
Anticancer Res. 2014 May;34(5):2223-9.
Formyl peptide receptor 1 (FPR1) as a regulator of innate inflammatory response has been implicated in tumor progression of gliomas. The purpose of the present study was to evaluate the prognostic significance and the ligand-receptor interaction of FPR1 in gastric cancer (GC).
FPR1 was immunohistochemically-analyzed in tissue sections originating from 116 GC patients. Reverse transcription-polymerase chain reaction (RT-PCR) was used for the assessment of interaction between FPR1 and the FPR1 ligand annexin A1 (AnxA1) in GC cells.
High FPR1 expression was significantly associated with stage IV disease, submucosal invasion, serosal invasion, and clinical outcome of GC. Multivariate analysis showed that high FPR1 expression was an independent risk factor of poor overall survival in GC patients. FPR1 expression increased significantly when AnxA1 overexpression was present in GC cells. A positive feedback regulation of FPR1 was involved in the AnxA1-FPR1 signal transduction.
FPR1 expression may be used as a novel indicator to predict outcome in GC patients after gastrectomy.
甲酰肽受体1（FPR1）作为先天炎症反应的调节因子，已被证明与胶质瘤的肿瘤进展有关。本研究旨在评估FPR1在胃癌（GC）中的预后意义以及配体-受体相互作用。
对116例GC患者的组织切片进行FPR1免疫组织化学分析。采用逆转录-聚合酶链反应（RT-PCR）评估GC细胞中FPR1与FPR1配体膜联蛋白A1（AnxA1）之间的相互作用。
FPR1高表达与GC的IV期疾病、黏膜下浸润、浆膜浸润及临床结局显著相关。多因素分析表明，FPR1高表达是GC患者总生存不良的独立危险因素。当GC细胞中存在AnxA1过表达时，FPR1表达显著增加。FPR1的正反馈调节参与了AnxA1-FPR1信号转导。
FPR1表达可作为预测GC患者胃切除术后预后的新指标。
