一种预测老年患者脑转移瘤单纯全脑放疗后生存预后的新评分系统。
A new score predicting survival prognosis after whole-brain radiotherapy alone for brain metastases in elderly patients.
作者信息
Evers Jasmin N, Schild Steven E, Segedin Barbara, Nagy Viorica, Khoa Mai Trong, Trang Ngo Thuy, Rades Dirk
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
出版信息
Anticancer Res. 2014 May;34(5):2455-8.
BACKGROUND/AIM: Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients.
PATIENTS AND METHODS
A total of 544 elderly patients (aged ≥65 years) receiving whole-brain radiotherapy alone were divided into a test (n=272) and a validation group (n=272). In the multivariate analysis of the test group, survival was significantly associated with gender, performance status, and number of organs involved by extracranial metastases. These factors were included in the score. Total scores representing the sum of the three factor scores were 3-13 points. Four prognostic groups were formed.
RESULTS
The 6-month survival rates were 2% for those with 3-6 points, 17% for those with 7-9 points, 56% for those with 10-12 points and 90% for those with 13 points in the test group (p<0.001), and 4%, 21%, 50% and 86%, respectively, in the validation group (p<0.001).
CONCLUSION
This score is reproducible and helps estimate the survival prognosis of elderly patients with brain metastasis.
背景/目的：老年患者是脑转移瘤患者中的一个重要亚组。已专门为这些患者制定了一个生存评分。
患者与方法
总共544例仅接受全脑放疗的老年患者（年龄≥65岁）被分为试验组（n = 272）和验证组（n = 272）。在试验组的多因素分析中，生存与性别、体能状态以及颅外转移累及的器官数量显著相关。这些因素被纳入评分。代表三个因素评分总和的总分是3 - 13分。形成了四个预后组。
结果
试验组中，3 - 6分者的6个月生存率为2%，7 - 9分者为17%，10 - 12分者为56%，13分者为90%（p < 0.001）；验证组中分别为4%、21%、50%和86%（p < 0.001）。
结论
该评分具有可重复性，有助于评估老年脑转移瘤患者的生存预后。
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