Park Min-Su, Lee Sang-Mok
Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Anticancer Res. 2014 May;34(5):2551-4.
(18)F-Fluorodeoxyglucose positron-emission with computed tomography ((18)F-FDG PET-CT) is an imaging technique based on the increased uptake of glucose characteristically seen in malignant lesions. The preoperative maximum standardized uptake value (SUVmax) of PET-CT has been identified as a powerful significant prognostic factor for predicting recurrence in malignant tumors. Therefore, the aim of this study was to determine whether (18)F-FDG PET-CT has a prognostic significance in patients with biliary tract cancer after surgical resection. From April 2006 to February 2013, 64 patients who underwent curative resection for biliary tract cancer were reviewed retrospectively. Clinical diagnoses of patients were: intrahepatic cholangio-carcinoma (n=6), hilar cholangiocarcinoma (n=6), extrahepatic cholangiocarcinoma (n=22), gall bladder cancer (n=14) and ampullar cancer (n=16). The mean preoperative SUVmax value was 5.1±4.7. The mean follow-up duration was 27 months. Recurrence-free survival at 1, 2 and 5 years were 75.9%, 63.3% and 47.1%. In the univariate analysis, N stage, poor tumor differentiation, the presence of lymphatic invasion and high SUVmax (>5.0) were significant risk factors for recurrence. The multivariate analysis showed a high preoperative SUVmax (>5.0) to be an independent risk factor for tumor recurrence (p=0.008). In conclusion, preoperative SUVmax of the primary tumor was significantly associated with recurrence in patients with biliary tract cancer.
（18）氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描（（18）F-FDG PET-CT）是一种基于恶性病变中葡萄糖摄取增加这一特征的成像技术。PET-CT术前最大标准化摄取值（SUVmax）已被确定为预测恶性肿瘤复发的有力显著预后因素。因此，本研究的目的是确定（18）F-FDG PET-CT在胆管癌手术切除患者中是否具有预后意义。回顾性分析了2006年4月至2013年2月期间64例行胆管癌根治性切除的患者。患者的临床诊断为：肝内胆管癌（n = 6）、肝门部胆管癌（n = 6）、肝外胆管癌（n = 22）、胆囊癌（n = 14）和壶腹癌（n = 16）。术前平均SUVmax值为5.1±4.7。平均随访时间为27个月。1年、2年和5年无复发生存率分别为75.9%、63.3%和47.1%。单因素分析中，N分期、肿瘤低分化、存在淋巴侵犯和高SUVmax（>5.0）是复发的显著危险因素。多因素分析显示术前高SUVmax（>5.0）是肿瘤复发的独立危险因素（p = 0.008）。总之，原发性肿瘤术前SUVmax与胆管癌患者的复发显著相关。
