Lemery R, Talajic M, Nattel S, Theroux P, Roy D
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
Pacing Clin Electrophysiol. 1989 Oct;12(10):1607-12. doi: 10.1111/j.1540-8159.1989.tb01839.x.
Encainide, a class Ic drug, is generally thought of as having little effect on sinus node function. In this article, we present the clinical course and electrophysiological findings of a patient who had cardiac arrest after 1 week of encainide therapy for ventricular extrasystoles. No ventricular tachyarrhythmias were induced during programmed ventricular stimulation (baseline study and while receiving encainide therapy). Prior to encainide therapy, sinus node function was normal, but clinical observations after admission for cardiac arrest and subsequent electrophysiological study revealed that encainide had caused striking impairments in sinus node function. During a 6-month follow-up without antiarrhythmic drug treatment, this patient has had an uneventful course. We concluded that encainide can cause severe and life-threatening sinus node dysfunction.
恩卡尼，一种Ic类药物，通常被认为对窦房结功能影响很小。在本文中，我们报告了一名患者的临床病程及电生理检查结果，该患者在接受恩卡尼治疗室性早搏1周后发生心脏骤停。在程序心室刺激期间（基线研究及接受恩卡尼治疗时）未诱发室性快速心律失常。在开始恩卡尼治疗前，窦房结功能正常，但在因心脏骤停入院后的临床观察及随后的电生理研究显示，恩卡尼已导致窦房结功能显著受损。在未进行抗心律失常药物治疗的6个月随访期间，该患者病情平稳。我们得出结论，恩卡尼可导致严重且危及生命的窦房结功能障碍。
