Beck A, Nanko N, Schildge J, Hasse J
Abteilung für Röntgendiagnostik, Radiologische Universitätsklinik, Freiburg.
Radiologe. 1989 Aug;29(8):399-405.
Imminent asphyxia due to tracheal or bronchial compression by inoperable tumors in the mediastinum and the central bronchi is serious, particularly if alternative treatments, i.e., radiation or chemotherapy, have been exhausted. For that reason, stents of different diameters and lengths were developed that could be dilated. With the patient under general anesthesia these stents can be introduced into the stenotic bronchus or trachea through a rigid bronchoscope. The appropriate stent is mounted on a 3-mm balloon catheter, which is inflated after the stent is in the correct position. Positioning is done under direct bronchoscopic and fluoroscopic control. After deflation of the balloon, the stent maintains its cross-sectional shape and keeps the airway open. The first clinical application was in a 53-year-old patient with end-stage small-cell carcinoma. The patient had had a relapse after combined chemo- and radiotherapy and had severe stridor. Stent insertion led to a significant relief of symptoms. The second patient, a 53-year-old woman who suffered from collapse of the bronchus caused by a radionecrosis, was treated by the same method. Nine months later, ventilation is excellent in the left lung, and the patient can tolerate the stent without any clinical symptoms. A 69-year-old woman suffered from a tracheal carcinoma with severe tracheal stenosis. It was possible to maintain the stability of the collapsed tracheal wall by insertion of a tracheal stent. This new technique can provide good palliative treatment and is sometimes even the main therapy in such cases.
纵隔和中央支气管无法手术切除的肿瘤导致气管或支气管受压引起的急性窒息情况严重,尤其是在放疗或化疗等替代治疗手段已经用尽的情况下。因此,研发出了不同直径和长度且可扩张的支架。在患者全身麻醉状态下,这些支架可通过硬支气管镜被置入狭窄的支气管或气管。合适的支架安装在3毫米的球囊导管上,待支架处于正确位置后将球囊充气。定位在直接支气管镜和荧光镜控制下进行。球囊放气后,支架保持其横截面形状并使气道保持通畅。首例临床应用是在一名53岁的终末期小细胞癌患者身上。该患者在放化疗联合治疗后复发,伴有严重的喘鸣。支架置入显著缓解了症状。第二例患者是一名53岁女性,因放射性坏死导致支气管塌陷,采用相同方法进行治疗。九个月后,左肺通气良好,患者能够耐受支架且无任何临床症状。一名69岁女性患有气管癌并伴有严重气管狭窄。通过插入气管支架能够维持塌陷气管壁的稳定性。这项新技术可提供良好的姑息治疗,在这类病例中有时甚至是主要治疗方法。