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脐带血在人类健康方面的临床应用：韩国脐带血干细胞移植和细胞治疗的经验。

Clinical utilization of cord blood over human health: experience of stem cell transplantation and cell therapy using cord blood in Korea.

作者信息

Lee Young-Ho

机构信息

Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.

出版信息

Korean J Pediatr. 2014 Mar;57(3):110-6. doi: 10.3345/kjp.2014.57.3.110. Epub 2014 Mar 31.

DOI:10.3345/kjp.2014.57.3.110
PMID:24778692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4000756/
Abstract

Cord blood (CB) has been used as an important and ethical source for hematopoietic stem cell transplantation (SCT) as well as cell therapy by manufacturing mesenchymal stem cell, induced pleuripotential stem cell or just isolating mononuclear cell from CB. Recently, the application of cell-based therapy using CB has expanded its clinical utility, particularly, by using autologous CB in children with refractory diseases. For these purposes, CB has been stored worldwide since mid-1990. In this review, I would like to briefly present the historical development of clinical uses of CB in the fields of SCT and cell therapy, particularly to review the experiences in Korea. Furthermore, I would touch the recent banking status of CB.

摘要

脐带血（CB）已成为造血干细胞移植（SCT）以及细胞治疗的重要且符合伦理的来源，通过制造间充质干细胞、诱导多能干细胞，或者仅从脐带血中分离单个核细胞来实现。最近，使用脐带血进行的细胞治疗应用扩大了其临床用途，特别是在难治性疾病儿童中使用自体脐带血。出于这些目的，自20世纪90年代中期以来，脐带血已在全球范围内储存。在本综述中，我想简要介绍脐带血在SCT和细胞治疗领域临床应用的历史发展，特别是回顾韩国的经验。此外，我还将探讨脐带血最近的储存情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/d591556e6835/kjped-57-110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/8d18a5026ce6/kjped-57-110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/f8b43cd9d307/kjped-57-110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/d591556e6835/kjped-57-110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/8d18a5026ce6/kjped-57-110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/f8b43cd9d307/kjped-57-110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/447a/4000756/d591556e6835/kjped-57-110-g003.jpg

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J Transl Med. 2013 Aug 27;11:196. doi: 10.1186/1479-5876-11-196.
2
A proposal for improvement in the utilization rate of banked cord blood.提高库存脐带血利用率的建议。
Blood Res. 2013 Mar;48(1):5-7. doi: 10.5045/br.2013.48.1.5.
3
Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial.
促红细胞生成素增强脐带血治疗脑瘫患儿的疗效：一项双盲、随机、安慰剂对照试验。
Stem Cells. 2013 Mar;31(3):581-91. doi: 10.1002/stem.1304.
4
Impact of donor-specific anti-HLA antibodies on graft failure and survival after reduced intensity conditioning-unrelated cord blood transplantation: a Eurocord, Société Francophone d'Histocompatibilité et d'Immunogénétique (SFHI) and Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) analysis.供者特异性抗 HLA 抗体对非亲缘性脐血移植后移植物失败和存活的影响：Eurocord、法国组织相容性和免疫遗传学学会（SFHI）和法国骨髓和细胞治疗移植学会（SFGM-TC）的分析。
Haematologica. 2013 Jul;98(7):1154-60. doi: 10.3324/haematol.2012.077685. Epub 2012 Dec 14.
5
Rescuing the neonatal brain from hypoxic injury with autologous cord blood.用自体脐血抢救缺氧性脑损伤新生儿。
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