关于宫颈鳞状上皮内病变的细胞学和组织病理学方面

Cytological and histopathological aspects concerning preinvasive squamous cervical lesions.

作者信息

Muntean Mihaela, Simionescu Cristiana, Taslîcă Rodica, Gruia Corina, Comanescu A, Pătrană Nicoleta, Fota Georgiana

机构信息

Pathological Anatomy Laboratory, Slatina Emergency County Hospital.

Department of Morfopathology, Faculty of Medicine, University of Medicine and Pharmacy, Craiova.

出版信息

Curr Health Sci J. 2010 Jan;36(1):26-32. Epub 2010 Mar 24.

PMID:24778824

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3945269/

Abstract

Our study was carried out on a total number of 158 patients, with a mean age of 32, all tested and identified cytologically (Pap-test) as presenting minor cellular abnormalities, respectively ASCUS (10) and LSIL (119), and major cellular abnormalities, respectively SIL-borderline (8) and HSIL (21), and who, either voluntarily or upon cytopathologists' recommendation, were colposcopically examined. Subsequently, they were subjected to cervical biopsy or excision therapy. In patients with ASCUS cytology, 6 cases were morphologically diagnosed with benign cervical lesions, 3 were diagnosed with LSIL, and one patient was diagnosed as HSIL (CIN 2). Out of 119 LSIL smears 108 were confirmed by histopathology, while 11 were diagnosed as HSIL (CIN 2). In SIL-borderline patients, 5 cases were screened as LSIL and 3 as HSIL. In patients with HSIL cytology, 18 were diagnosed histopathologically as HSIL (CIN 2 and CIN 3/CIS), while 3 were diagnosed as invasive squamous carcinoma.

摘要

我们的研究共纳入了158例患者，平均年龄为32岁，所有患者均经细胞学检查（巴氏试验），分别被确定为存在轻度细胞异常，即非典型鳞状细胞（ASCUS，10例）和低度鳞状上皮内病变（LSIL，119例），以及重度细胞异常，即鳞状上皮内病变-交界性（SIL-交界性，8例）和高度鳞状上皮内病变（HSIL，21例），并且这些患者均自愿或根据细胞病理学家的建议接受了阴道镜检查。随后，他们接受了宫颈活检或切除治疗。在ASCUS细胞学检查的患者中，6例经形态学诊断为宫颈良性病变，3例诊断为LSIL，1例患者诊断为HSIL（CIN 2）。在119例LSIL涂片检查中，108例经组织病理学确诊，11例诊断为HSIL（CIN 2）。在SIL-交界性患者中，5例筛查为LSIL，3例为HSIL。在HSIL细胞学检查的患者中，18例经组织病理学诊断为HSIL（CIN 2和CIN 3/CIS），3例诊断为浸润性鳞状细胞癌。