Tomaziu-Todosia Anton Ecaterina, Anton Gabriel-Ioan, Scripcariu Ioana-Sadiye, Dumitrașcu Irina, Scripcariu Dragos Viorel, Balmus Ioana-Miruna, Ionescu Cătălina, Visternicu Mălina, Socolov Demetra Gabriela
Department of Obstetrics and Gynecology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, University Street, No. 16, 700115 Iasi, Romania.
Department of Obstetrics and Gynecology, Clinical Hospital of Obstetrics and Gynecology "Cuza Voda", Cuza Voda Street, No. 34, 700038 Iasi, Romania.
Int J Mol Sci. 2025 May 21;26(10):4961. doi: 10.3390/ijms26104961.
Cervical cancer ranks third among malignant diseases of the female reproductive system and progressively develops through a series of pathological changes known as cervical intraepithelial neoplasia (CIN). Despite being extremely aggressive and causing increased mortality, the main treatment options include surgery or a combination of chemotherapy and radiotherapy, often based on cisplatin-based chemotherapy and external beam radiotherapy or brachytherapy. Cervical dysplasia is an abnormal growth of cells on the surface of the cervix that could lead to cervical cancer. CIN most commonly occurs at the squamocolumnar junction of the cervix, a transitional zone between the squamous epithelium of the vagina and the columnar epithelium of the endocervix. The primary cause of CIN is chronic infection of the cervix with Human Papillomavirus (HPV). Oxidative stress (OS) and chronic inflammation are associated with HPV-induced cervical dysplasia. Reactive oxygen species (ROS) facilitate the progression of CIN through DNA damage, immune evasion, and cellular mutations. Thus, the inflammatory environment, characterized by increased expression of proinflammatory cytokines, contributes to epithelial transformation. Given these mechanisms, antioxidants, including vitamins A, C, D, E, polyphenols, and carotenoids, are being investigated for their potential as adjunctive therapies in CIN management. This review aims to provide a comprehensive analysis of the influence of oxidative stress, antioxidants, and inflammation on cervical cancer.
宫颈癌在女性生殖系统恶性疾病中排名第三，它通过一系列被称为宫颈上皮内瘤变（CIN）的病理变化逐步发展。尽管宫颈癌极具侵袭性且死亡率不断上升，但其主要治疗选择包括手术或化疗与放疗的联合，通常基于以顺铂为基础的化疗以及外照射放疗或近距离放疗。宫颈发育异常是宫颈表面细胞的异常生长，可能导致宫颈癌。CIN最常发生在宫颈的鳞柱交界区，即阴道鳞状上皮和宫颈管柱状上皮之间的过渡区域。CIN的主要病因是宫颈受到人乳头瘤病毒（HPV）的慢性感染。氧化应激（OS）和慢性炎症与HPV诱导的宫颈发育异常有关。活性氧（ROS）通过DNA损伤、免疫逃逸和细胞突变促进CIN的进展。因此，以促炎细胞因子表达增加为特征的炎症环境有助于上皮细胞转化。鉴于这些机制，正在研究包括维生素A、C、D、E、多酚和类胡萝卜素在内的抗氧化剂作为CIN治疗辅助疗法的潜力。本综述旨在全面分析氧化应激、抗氧化剂和炎症对宫颈癌的影响。
