Böhmer Frank-D, Friedrich Karlheinz
Institute of Molecular Cell Biology; CMB; Jena University Hospital; Jena, Germany.
Institute of Biochemistry II; Jena University Hospital; Jena, Germany.
JAKSTAT. 2014 Jan 1;3(1):e28087. doi: 10.4161/jkst.28087. Epub 2014 Feb 20.
Signaling by signal transducers and activators of transcription (STATs) is controlled at many levels of the signaling cascade. Protein tyrosine phosphatases (PTPs) regulate STAT activation at several layers, including direct pSTAT dephosphorylation in both cytoplasm and nucleus. Despite the importance of this regulation mode, many aspects are still incompletely understood, e.g., the identity of PTPs acting on certain members of the STAT family. After a brief introduction into the STAT and PTP families, we discuss here the current knowledge on PTP mediated regulation of STAT activity, focusing on the interaction of individual STATs with specific PTPs. Finally, we highlight open questions and propose important tasks of future research.
信号转导及转录激活因子(STATs)介导的信号传导在信号级联反应的多个层面受到调控。蛋白酪氨酸磷酸酶(PTPs)在多个层面调节STAT的激活,包括在细胞质和细胞核中直接使磷酸化的STAT(pSTAT)去磷酸化。尽管这种调控模式很重要,但许多方面仍未完全了解,例如作用于STAT家族某些成员的PTP的身份。在简要介绍STAT和PTP家族之后,我们在此讨论目前关于PTP介导的STAT活性调控的知识,重点是单个STAT与特定PTP的相互作用。最后,我们强调了悬而未决的问题,并提出了未来研究的重要任务。