JAK/STAT信号通路中的蛋白酪氨酸磷酸酶
Protein tyrosine phosphatases in the JAK/STAT pathway.
作者信息
Xu Dan, Qu Cheng-Kui
机构信息
Department of Medicine, Division of Hematology/Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
Front Biosci. 2008 May 1;13:4925-32. doi: 10.2741/3051.
Abstract
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial in controlling cellular activities in response to extracellular cytokines. Dysfunctions of the JAK/STAT pathway result in various hematopoietic and immune disorders. The central events in regulating this pathway are tyrosine phosphorylation and dephosphorylation of the signaling components, which are carried out by protein tyrosine kinases and protein tyrosine phosphatases (PTP), respectively. Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway.
摘要
Janus激酶（JAK）/信号转导及转录激活因子（STAT）通路在控制细胞对细胞外细胞因子的反应活动中至关重要。JAK/STAT通路功能失调会导致多种造血和免疫紊乱。调节该通路的核心事件是信号成分的酪氨酸磷酸化和去磷酸化，分别由蛋白酪氨酸激酶和蛋白酪氨酸磷酸酶（PTP）执行。在此，我们综述了PTP，特别是SHP2磷酸酶，在JAK/STAT信号通路中的调节作用的最新进展。
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本文引用的文献
1
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Mol Cell Biol. 2007 Oct;27(19):6706-17. doi: 10.1128/MCB.01225-07. Epub 2007 Jul 23.
2
JAK-STAT signaling: from interferons to cytokines.
J Biol Chem. 2007 Jul 13;282(28):20059-63. doi: 10.1074/jbc.R700016200. Epub 2007 May 14.
3
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4060-4. doi: 10.1073/pnas.0611665104. Epub 2007 Feb 21.
4
Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.
Immunity. 2007 Feb;26(2):163-76. doi: 10.1016/j.immuni.2007.01.010.
5
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}.
Blood. 2007 May 15;109(10):4220-8. doi: 10.1182/blood-2006-08-044370. Epub 2007 Jan 18.
6
The role of Shp2 (PTPN11) in cancer.
Curr Opin Genet Dev. 2007 Feb;17(1):23-30. doi: 10.1016/j.gde.2006.12.011. Epub 2007 Jan 16.
7
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Blood. 2007 Feb 1;109(3):862-7. doi: 10.1182/blood-2006-07-028829. Epub 2006 Oct 19.
8
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.
J Biol Chem. 2006 Nov 10;281(45):34374-80. doi: 10.1074/jbc.M607325200. Epub 2006 Sep 7.
9
Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma.
Leukemia. 2006 Sep;20(9):1602-9. doi: 10.1038/sj.leu.2404323. Epub 2006 Jul 27.
10
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma.
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