Chissov V I, Mamontov A S, Rusakov I G, Shchitkov K G, Akimova A Ia, Il'ina A I, Volokhov A B, Akhmetov M M
Sov Med. 1989(7):28-31.
Antitumor efficacy of a medical adhesive MK-8-based polymer drug composition with prospidin has been studied in 49 Wistar rats, and the kinetics of the drug elimination has been followed up in 112 rats. The findings evidence a prolongation of a relapse-free period and a longer survival of the animals. Clinical trials of the composition have been carried out. Of the 70 patients with esophageal carcinomas 52 ones had local disseminated forms, conforming to T4P3-4 indices. Application of the adhesive composition has not increased the rate of postoperative complications and in some cases considerably prolonged the life span of patients after palliative surgery.
已在49只Wistar大鼠中研究了含脯氨脒的基于医用粘合剂MK-8的聚合物药物组合物的抗肿瘤功效，并在112只大鼠中跟踪了药物消除动力学。研究结果表明无复发期延长，动物存活时间更长。已对该组合物进行了临床试验。在70例食管癌患者中，52例为局部播散型，符合T4P3-4指标。应用该粘合剂组合物并未增加术后并发症的发生率，在某些情况下还显著延长了姑息手术后患者的寿命。
