Hadders-Algra M, Huisjes H J, Touwen B C
Instituut voor Ontwikkelingsneurologie, Academisch Ziekenhuis Groningen.
Tijdschr Kindergeneeskd. 1989 Jun;57(3):77-81.
A follow-up study at six and/or nine years of age was carried out on subpopulations of the three years cohort of the Groningen Perinatal Project. Neurological handicap and minor neurological dysfunction (MND) were associated with different sets of risk factors. The findings suggest a temporal difference in potentially harmful factors. At nine years of age two different kinds of MND could be distinguished, each of them related in a specific way to perinatal risk factors and behavioural and cognitive development. The finding that social factors, sex and present neurological condition of the child appeared to be more important than pre- and perinatal events for the development of learning and behavioural problems illustrates the complex aetiology of the latter.
对格罗宁根围产期项目三年队列中的亚人群进行了6岁和/或9岁的随访研究。神经残疾和轻度神经功能障碍(MND)与不同的风险因素相关。研究结果表明潜在有害因素存在时间差异。在9岁时,可以区分出两种不同类型的MND,它们各自以特定方式与围产期风险因素以及行为和认知发展相关。研究发现,对于学习和行为问题的发展而言,社会因素、孩子的性别和当前神经状况似乎比产前和围产期事件更为重要,这说明了后者病因的复杂性。