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[生育次数与初潮作为绝经后女性骨质疏松症的风险因素]

[Parity and menarche as risk factors for osteoporosis in postmenopausal women].

作者信息

Mendoza-Romo Miguel Angel, Ramírez-Arriola Mariá Cleofás, Velasco-Chávez José Fernando, Rivera-Martínez José Guillermo, de Jesús Rafael Natividad Nieva, Valdez-Jiménez Luis Alvaro

出版信息

Ginecol Obstet Mex. 2014 Feb;82(2):75-82.

Abstract

BACKGROUND

Worldwide studies, even in our country, have thrown discrepant results about the relation between osteoporosis, parity and age of menarche.

OBJECTIVE

To investigate the relation of osteoporosis in postmenopausal mexican women with multiparity and age of menarche.

PATIENTS AND METHOD

Transversal, retrospective and analytical study. Non-probabilistic sampling technique was performing with users women of the IMSS in San Luis Potosí. Reproductive history and age of menarche were obtained by the addition of these items to the previously validated Albrand questionnaire. Women were divided into groups according to the number of pregnancies in: normal parity (0 to 3 childbirths) conformed by 112 patients (46%) and multiparity (> or = 4 pregnancies), 131 women (54%). In relation to menarche with an average of 12.98 years, from this number we divided them in: early menarche (before the age of 13) and late menarche (at 13 years of age or after). It was measured bone mineral density with dual distal forearm x-ray absorptiometry to all patients.

RESULTS

243 women were studied, with an average of age of 55.92, rank 31 to 80 years. Using the criteria, of the World Health Organization, 18% of posmenopausal women had osteoporosis, 39% had osteopenia and 41% had bone normality. No association was found between the number of deeds and osteoporosis. Additionally we observed that the women who had 4 or more children were older than the other women. average 57.42 against 54.16. Also there was significant negative correlation (r = -0.43) between age and densitometry. In addition we found that an age greater to 13 years in the appearance of the menarche was related to osteoporosis (OR 4.46; p = 0.035).

CONCLUSIONS

In posmenopausal women a menarche at the age of 13 years or after is a risk factor for osteoporosis.

摘要

背景

全球范围内的研究,甚至在我国,关于骨质疏松症、生育次数和初潮年龄之间的关系都得出了不一致的结果。

目的

研究墨西哥绝经后多产妇女的骨质疏松症与初潮年龄之间的关系。

患者与方法

横向、回顾性和分析性研究。采用非概率抽样技术,对圣路易斯波托西市墨西哥社会保险局(IMSS)的女性使用者进行研究。通过在先前验证过的阿尔布兰德问卷中增加这些项目来获取生殖史和初潮年龄。根据怀孕次数将女性分为两组:正常生育组(0至3次分娩),由112名患者组成(46%);多产组(≥4次怀孕),131名女性(54%)。关于初潮,平均年龄为12.98岁,据此将她们分为:初潮早(13岁之前)和初潮晚(13岁及以后)。对所有患者采用双能远端前臂X线吸收法测量骨密度。

结果

共研究了243名女性,平均年龄为55.92岁,年龄范围为31至80岁。根据世界卫生组织的标准,18%的绝经后女性患有骨质疏松症,39%患有骨量减少,41%骨量正常。未发现生育次数与骨质疏松症之间存在关联。此外,我们观察到生育4个或更多孩子的女性比其他女性年龄更大。平均年龄分别为57.42岁和54.16岁。年龄与骨密度测量值之间也存在显著的负相关(r = -0.43)。此外,我们发现初潮年龄大于13岁与骨质疏松症有关(比值比4.46;p = 0.035)。

结论

在绝经后女性中,13岁及以后初潮是骨质疏松症的一个危险因素。

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